DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3534 and CG3544

DIOPT Version :9

Sequence 1:	NP_650582.1	Gene:	CG3534 / 42047	FlyBaseID:	FBgn0038463	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_001259842.1	Gene:	CG3544 / 33252	FlyBaseID:	FBgn0031279	Length:	572	Species:	Drosophila melanogaster

Alignment Length:	555	Identity:	254/555 - (45%)
Similarity:	370/555 - (66%)	Gaps:	15/555 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 TFLGFDLSTQKLKAVLLGSSLEVVAAAEVKFDTDLPEFRTTGGANAGSIKNEYFVQPVMWVKAMD 74
            ::||..|.||..:|::|.|.|.|...|::::|.|||||:||.|..:.....|:...|||||||:|
  Fly    13 SYLGLHLGTQLFRALILDSKLNVTYVAQIRYDVDLPEFKTTNGILSDGGPGEFLANPVMWVKALD 77

  Fly    75 IVLDRLVMQQADLSTVAAISGSGQQHGSLYWSKHGINTLQNLDSEKFLHAQIDDSAFVVNRTPIW 139
            :::|.||.|.||:.||.:|:|:.||||.::||:.|:..|.||:....||.||.:|||.:.|||.|
  Fly    78 MLMDCLVKQGADMHTVVSIAGAAQQHGCVFWSELGLRRLCNLNVNLRLHEQITESAFELTRTPTW 142

  Fly   140 MDATTTKQCLEMEMAVGGKLNMVELTGSKCYERFTGPQIRKIYQQRCHAYEEANRISLVSSFISS 204
            .|::|..|..|||..|||...:.::|||:.|.|||||||||:|.|....||..:||||:|||::|
  Fly   143 RDSSTDVQVREMEHTVGGPAELSKITGSRAYTRFTGPQIRKVYTQCPEQYERTSRISLISSFLAS 207

  Fly   205 LFLGSVAPIDFSDGSGMNLLDIRKKNWSKECLNVCAPDLDKRLDIPVSPNSILGNVSPYFVERFS 269
            |.:|.:|.||:||||||||||||||.||..||:.|||||.:||..|:..:.:.|.:..|:|:|::
  Fly   208 LLIGGIASIDYSDGSGMNLLDIRKKKWSAACLDACAPDLARRLMKPIPSSRLQGRIGDYYVKRWN 272

  Fly   270 FSPDCKVAASTGDNPSALSGMLVGSSWLTISMGTSDTLMMSLKEPLNWEEGHILCHPTETEEFMG 334
            |.|||.|.||||...|.|:|:||.:.:|.:|:.|||.::|.||:....|:||::||||..:|:||
  Fly   273 FRPDCMVVASTGSKASELAGLLVENDFLMLSLDTSDVVVMPLKKAPRLEDGHVMCHPTRRDEYMG 337

  Fly   335 LLCFRNASLVREEMNKKTTGGDWDKFNEYLDSTPRGNFGNMAVHFNDMEIIPKAQGILRWNREMD 399
            ||||:|..|.|:.:.:...||.|..|.|.||:||.||.||:||||.|.||||.|:|.|||:..:.
  Fly   338 LLCFQNGGLTRKAICEDVAGGSWRHFYEMLDATPSGNNGNVAVHFRDREIIPTAKGTLRWDAHIS 402

  Fly   400 PSSPDAARGVIKFSSPQIEIRALVEGQMLHHRAVAEDLGYKFGPETQILVTGGASVNKSILQTIA 464
            |.|.:..||:.:||:|:||:|||:|||::||.::|.::|:...|.|:|:|.|..|..:|:||.:|
  Fly   403 PMSAECIRGLHRFSTPEIEVRALIEGQIMHHWSIAHEMGFHHTPNTKIIVVGEDSRCQSVLQIVA 467

  Fly   465 DVFNAPVHIQDEGFEAALLGAAYRSAYALY------------LQEAGDGVTPLCYRDYILSLTSN 517
            |:|||||: |..|.|.:|||.|:|:.||.|            :...|.. |.|.:.::...:.|.
  Fly   468 DIFNAPVY-QRTGVEVSLLGCAFRARYAFYEHRESACNCHSCMMPTGRR-TRLSFDEFFRDVPSG 530

  Fly   518 KLSLVCEPHKDSEEIYAPMLQRYREMARVLSNPNT 552
             |.|..||....::||.|:::|..::.::|::.::
  Fly   531 -LKLAAEPTPGCDKIYKPLIERCSQICQLLASKSS 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3534	NP_650582.1	FGGY_D-XK_euk	10..491	CDD:212660	238/480 (50%)
		PLN02669	11..546	CDD:178274	253/546 (46%)
		NBD_sugar-kinase_HSP70_actin	<447..545	CDD:302596	37/109 (34%)
CG3544	NP_001259842.1	FGGY_D-XK_euk	13..493	CDD:212660	238/480 (50%)
CG3544	NP_001259842.1	XylB	15..494	CDD:273550	238/479 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443067
Domainoid	1	1.000	158	1.000	Domainoid score	I1293
eggNOG	1	0.900	-	-		E1_COG1070
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	374	1.000	Inparanoid score	I552
Isobase	1	0.950	-	0	Normalized mean entropy	S1469
OMA	1	1.010	-	-		QHG56396
OrthoDB	1	1.010	-	-		D335934at33208
OrthoFinder	1	1.000	-	-		FOG0004391
OrthoInspector	1	1.000	-	-		otm26509
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10196
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3110
	12	11.860