DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3534 and Xylb

DIOPT Version :9

Sequence 1:	NP_650582.1	Gene:	CG3534 / 42047	FlyBaseID:	FBgn0038463	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	XP_038937568.1	Gene:	Xylb / 316067	RGDID:	1307372	Length:	663	Species:	Rattus norvegicus

Alignment Length:	554	Identity:	245/554 - (44%)
Similarity:	349/554 - (62%)	Gaps:	25/554 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGPPKQL-----KRTFLGFDLSTQKLKAVLLGSSLEVVAAAEVKFDTDLPEFRTTGGANAGSIKN 60
            :|.||.:     :|..||:|.|||::|.|.:.:.|.|.....|.||.|||||.|.||.:....:.
  Rat   122 VGTPKTMAERAGRRCCLGWDFSTQQVKVVAVDAELNVFYEDSVHFDRDLPEFGTQGGVHVHKDRL 186

  Fly    61 EYFVQPVMWVKAMDIVLDRLVMQQADLSTVAAISGSGQQHGSLYWSKHGINTLQNLDSEKFLHAQ 125
            ......:|||:|:|::|:::.....|.|.|.|:||:||||||:||.......|.:|.....||.|
  Rat   187 TVTSPVLMWVQALDLILEKMKASGFDFSQVLALSGAGQQHGSVYWKTGASLALSSLSPALLLHQQ 251

  Fly   126 IDDSAFVVNRTPIWMDATTTKQCLEMEMAVGGKLNMVELTGSKCYERFTGPQIRKIYQQRCHAYE 190
            : .:.|.|:..|||||::||.||.::|.||||...:..||||:.||||||.||.||:|:...||.
  Rat   252 L-QACFSVSDCPIWMDSSTTAQCHQLEAAVGGAQALSCLTGSRAYERFTGNQISKIFQKNPEAYS 315

  Fly   191 EANRISLVSSFISSLFLGSVAPIDFSDGSGMNLLDIRKKNWSKECLNVCAPDLDKRLDIPVSPNS 255
            .:.||||||||.:|||||..:|||:|||||||||.|::|.||:.||:.|||.|.::|..||...|
  Rat   316 NSERISLVSSFAASLFLGGYSPIDYSDGSGMNLLQIQEKVWSQACLDACAPHLKEKLGSPVPSCS 380

  Fly   256 ILGNVSPYFVERFSFSPDCKVAASTGDNPSALSGMLVGSSWLTISMGTSDTLMMSLKEPLNWEEG 320
            ::|.:|.|:|:|:.|.|.|||.|.|||||::|:||.:....:.:|:||||||.:.|::|:...||
  Rat   381 VVGAISSYYVQRYGFPPGCKVVAFTGDNPASLAGMRLEEGDVAVSLGTSDTLFLWLQKPMPALEG 445

  Fly   321 HILCHPTETEEFMGLLCFRNASLVREEMNKKTTGGDWDKFNEYLDSTPRGNFGNMAVHFNDMEII 385
            ||.|:|.:..::|.||||:|.||:||::..::....|:||::.|.||..||.||:..:|:.|||.
  Rat   446 HIFCNPVDARQYMALLCFKNGSLMREKIRDESASCSWNKFSKALQSTEMGNNGNLGFYFDVMEIT 510

  Fly   386 PKAQGILRWNREMDPSSPDAARGVIKFSSPQIEIRALVEGQMLHHRAVAEDLGYKFGPETQILVT 450
            |:..|..|:|  .|.....|..|       .:|||||||||.:..|..||.|||:..|:|:||.|
  Rat   511 PEIIGCHRFN--ADNMEVSAFPG-------DVEIRALVEGQFMAKRIHAEGLGYRIMPKTKILAT 566

  Fly   451 GGASVNKSILQTIADVFNAPVHIQDEGFEAALLGAAYRSAYALYLQEAGDGVTPLCYRDYILSLT 515
            ||||.||.|||.:||||.|||::.|. ..:|.:|:|||:.:.|      .|.|.:.:.:.:.|
  Rat   567 GGASHNKDILQVLADVFGAPVYVIDT-TSSACVGSAYRAFHGL------AGGTGVAFSEVVKS-- 622

  Fly   516 SNKLSLVCEPHKDSEEIYAPMLQRYREM-ARVLS 548
            :.:.||...|:..:.::||.:|.||.|: .|:||
  Rat   623 APQPSLAATPNPGASQVYAALLPRYAELEQRILS 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3534	NP_650582.1	FGGY_D-XK_euk	10..491	CDD:212660	225/480 (47%)
		PLN02669	11..546	CDD:178274	238/535 (44%)
		NBD_sugar-kinase_HSP70_actin	<447..545	CDD:302596	38/98 (39%)
Xylb	XP_038937568.1	FGGY_D-XK_euk	136..606	CDD:212660	225/480 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337232
Domainoid	1	1.000	183	1.000	Domainoid score	I3361
eggNOG	1	0.900	-	-		E1_COG1070
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3746
Inparanoid	1	1.050	445	1.000	Inparanoid score	I1583
OMA	1	1.010	-	-		QHG56396
OrthoDB	1	1.010	-	-		D335934at33208
OrthoFinder	1	1.000	-	-		FOG0004391
OrthoInspector	1	1.000	-	-		otm45495
orthoMCL	1	0.900	-	-		OOG6_104017
Panther	1	1.100	-	-	LDO	PTHR10196
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3110
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770