DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3534 and R08D7.7

DIOPT Version :9

Sequence 1:	NP_650582.1	Gene:	CG3534 / 42047	FlyBaseID:	FBgn0038463	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_498988.2	Gene:	R08D7.7 / 187700	WormBaseID:	WBGene00011147	Length:	522	Species:	Caenorhabditis elegans

Alignment Length:	542	Identity:	188/542 - (34%)
Similarity:	294/542 - (54%)	Gaps:	36/542 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LKRTFLGFDLSTQKLKAVLLGSSLEVVAAAEVKFDT--DLPEFRTTGGANA-GSIKNEYFVQPV- 67
            :|..|||.|||||::|||::..:.:||....:.|.|  .|.:|.|..|.:. ||:    ...||
Worm     1 MKDGFLGIDLSTQQIKAVIIDQNGKVVHTTAINFSTHEKLKKFGTENGVHKNGSV----ITSPVI 61

  Fly    68 MWVKAMDIVLDRLVMQQADLSTVAAISGSGQQHGSLYWSKHGINTLQNLDSEKFLHAQIDDSAFV 132
            ||::|:||:.:.| .:......:..|||..||||::||.....|:|:.||..:.|..|: :..|.
Worm    62 MWIEAIDILFNDL-RENGWTDKLRGISGCAQQHGTVYWKNGAENSLKGLDESRSLAEQL-EMCFS 124

  Fly   133 VNRTPIWMDATTTKQCLEMEMAVGGKLNMVELTGSKCYERFTGPQIRKIYQQRCHAYEEANRISL 197
            |.::|||||::|.|||.|:|..|||...|.:||||:.:.||:..||:||..::...:::..::||
Worm   125 VQKSPIWMDSSTEKQCQELETFVGGDQEMAKLTGSRAHHRFSAAQIKKIVDEKQDVWKDTEKVSL 189

  Fly   198 VSSFISSLFLGSVAPIDFSDGSGMNLLDIRKKNWSKECLNVCAPDLDKRLDIPVSPNSILGNVSP 262
            :|||.:||.:|..|.|:.:|||||||::|:.:||.|...:..:.||:.:|...|.|.:..|:|..
Worm   190 ISSFFASLLIGKYALIELTDGSGMNLMNIKTENWHKPLFDFISSDLESKLGTLVHPMTSTGHVHS 254

  Fly   263 YFVERFSFSPDCKVAASTGDNPSALSGMLVGSSWLTISMGTSDTLMMSLK--EPLNWEEGHILCH 325
            |:..||....||.|....|||||:|:|:.:..:.:.||:|||||:.....  ||.  .:.|:..|
Worm   255 YWTRRFGIPSDCTVLPFLGDNPSSLAGLSLLPTDIGISLGTSDTVFFFTPTFEPN--IDAHVFSH 317

  Fly   326 PTETEEFMGLLCFRNASLVREEMNKKTTGGDWDKFNEYLDSTPRGNFGNMAVHFNDMEIIP-KAQ 389
            ......:|.::||:|.||.||.. :......|||:::.:..||.||...:...|::.||:| |.:
Worm   318 FAPNSGYMAMVCFKNGSLTRERA-RNLNNSSWDKWDKIMKKTPAGNDNYIGFFFDEDEIVPRKPK 381

  Fly   390 GILRWNREMDPSSPDAARGVIKFSSPQIEIRALVEGQMLHHRAVAEDLGYKFGPETQILVTGGAS 454
            |...:         :.:...:|...|:...||:.|.|.|......:.:|:|....::||||||||
Worm   382 GDYTF---------ECSEEELKNKHPEKFARAVFESQCLFKLLYTQKMGFKKSDCSRILVTGGAS 437

  Fly   455 VNKSILQTIADVFNAPVHIQDEGFEAALLGAAYRSAYALYLQEAGDGVTPLCYRDYILSLTSNKL 519
            .|..:||.::|||..||...|....|| ||.|.||.|.       ...|...|..|   ...:.:
Worm   438 RNTVLLQILSDVFEMPVCTIDVDGSAA-LGGAMRSRYV-------HSKTTKTYSQY---YPCDNV 491

  Fly   520 SLVCEPHKDSEEIYAPMLQRYR 541
            ||.|:|...:.|:|:.:.:.::
Worm   492 SLACQPISANVEVYSNLFKTFK 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3534	NP_650582.1	FGGY_D-XK_euk	10..491	CDD:212660	177/487 (36%)
		PLN02669	11..546	CDD:178274	187/538 (35%)
		NBD_sugar-kinase_HSP70_actin	<447..545	CDD:302596	34/95 (36%)
R08D7.7	NP_498988.2	XylB	1..515	CDD:223996	188/542 (35%)
R08D7.7	NP_498988.2	FGGY_D-XK_euk	5..473	CDD:212660	177/486 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157591
Domainoid	1	1.000	138	1.000	Domainoid score	I2995
eggNOG	1	0.900	-	-		E1_COG1070
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3746
Inparanoid	1	1.050	305	1.000	Inparanoid score	I1590
Isobase	1	0.950	-	0	Normalized mean entropy	S1469
OMA	1	1.010	-	-		QHG56396
OrthoDB	1	1.010	-	-		D335934at33208
OrthoFinder	1	1.000	-	-		FOG0004391
OrthoInspector	1	1.000	-	-		otm14509
orthoMCL	1	0.900	-	-		OOG6_104017
Panther	1	1.100	-	-	LDO	PTHR10196
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1675
SonicParanoid	1	1.000	-	-		X3110
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750