DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3534 and AgaP_AGAP000220

DIOPT Version :9

Sequence 1:	NP_650582.1	Gene:	CG3534 / 42047	FlyBaseID:	FBgn0038463	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	XP_310914.4	Gene:	AgaP_AGAP000220 / 1272047	VectorBaseID:	AGAP000220	Length:	556	Species:	Anopheles gambiae

Alignment Length:	543	Identity:	328/543 - (60%)
Similarity:	417/543 - (76%)	Gaps:	11/543 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 TFLGFDLSTQKLKAVLLGSSLEVVAAAEVKFDTDLPEFRTTGGANAGSIKNEYFVQPVMWVKAMD 74
            |:||.||||||||||||.::||.||.||||||:||||||||||.|.|:.|||::||||||:||:|
Mosquito     7 TYLGLDLSTQKLKAVLLNANLENVAHAEVKFDSDLPEFRTTGGVNVGTAKNEFYVQPVMWIKALD 71

  Fly    75 IVLDRLVMQQADLSTVAAISGSGQQHGSLYWSKHGINTLQNLDSEKFLHAQIDDSAFVVNRTPIW 139
            :||||:|:|.||||||.|:|||.|||||||||:.|::||::||::||||.|:|||||.|:|||||
Mosquito    72 MVLDRIVVQGADLSTVVALSGSAQQHGSLYWSRSGLDTLRHLDADKFLHTQLDDSAFTVHRTPIW 136

  Fly   140 MDATTTKQCLEMEMAVGGKLNMVELTGSKCYERFTGPQIRKIYQQRCHAYEEANRISLVSSFISS 204
            ||.||.:||.|||.||||:..|||:|||:|||||||||||:|:|||...|....||||||||::|
Mosquito   137 MDGTTGRQCEEMEAAVGGRERMVEITGSRCYERFTGPQIRRIFQQRPDCYRNTERISLVSSFLAS 201

  Fly   205 LFLGSVAPIDFSDGSGMNLLDIRKKNWSKECLNVCAPDLDKRLDIPVSPNSILGNVSPYFVERFS 269
            :|||.|||||.||||||||||:|.::||.|||..|||||..:|..||...:::|.:..:||:|::
Mosquito   202 VFLGEVAPIDCSDGSGMNLLDVRTRDWSDECLAACAPDLRAKLGAPVPAATVIGPIGSFFVQRYN 266

  Fly   270 FSPDCKVAASTGDNPSALSGMLVGSSWLTISMGTSDTLMMSLKEPLNWEEGHILCHPTETEEFMG 334
            |:..|:|.|.||||.|||:||.||..||.:|:|||||:||.|..|.|.:|||:|.|||: :.|||
Mosquito   267 FNTGCRVVAFTGDNLSALAGMNVGKDWLALSLGTSDTVMMRLNAPSNLQEGHVLVHPTD-DGFMG 330

  Fly   335 LLCFRNASLVREEMNKKTTGGDWDKFNEYLDSTPRGNFGNMAVHFNDMEIIPKAQGILRWNREMD 399
            ||||||.||||:...:.....:|:.|:|.|||||||||||:|:||...||:|..:|.||||:...
Mosquito   331 LLCFRNGSLVRDIFKRAEANDNWENFSELLDSTPRGNFGNLALHFLSKEILPPVKGSLRWNKNSS 395

  Fly   400 PSSPDAARGVIKFSSPQIEIRALVEGQMLHHRAVAEDLGYKFGPETQILVTGGASVNKSILQTIA 464
            .:|.:.|:||:|:||||.|||||||||||..:..|.::|:.||..|:||.|||||.|:||||.::
Mosquito   396 LASVELAKGVLKYSSPQSEIRALVEGQMLTRKTYATEMGFSFGESTKILATGGASANRSILQVVS 460

  Fly   465 DVFNAPVHIQDEGFEAALLGAAYRSAYALYL---QEA--GDG----VTPLCYRDYILSLTSNKLS 520
            |||||||:.| :..||||:|||||:.|.|.:   :||  |||    ..|..|.|:|..|..:.::
Mosquito   461 DVFNAPVYTQ-KTTEAALVGAAYRAKYVLSVARSREAPCGDGKGAVSAPGPYYDFIAGLLPHSVT 524

  Fly   521 LVCEPHKDSEEIYAPMLQRYREM 543
            .||:|.||||:||..|.:|||.|
Mosquito   525 RVCDPSKDSEQIYGAMEERYRAM 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3534	NP_650582.1	FGGY_D-XK_euk	10..491	CDD:212660	302/480 (63%)
		PLN02669	11..546	CDD:178274	327/542 (60%)
		NBD_sugar-kinase_HSP70_actin	<447..545	CDD:302596	55/106 (52%)
AgaP_AGAP000220	XP_310914.4	FGGY_D-XK_euk	7..486	CDD:212660	302/480 (63%)
AgaP_AGAP000220	XP_310914.4	XylB	9..489	CDD:273550	302/481 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	226	1.000	Domainoid score	I5532
eggNOG	1	0.900	-	-		E1_COG1070
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3746
Inparanoid	1	1.050	663	1.000	Inparanoid score	I2045
OMA	1	1.010	-	-		QHG56396
OrthoDB	1	1.010	-	-		D335934at33208
OrthoFinder	1	1.000	-	-		FOG0004391
OrthoInspector	1	1.000	-	-		oto108654
Panther	1	1.100	-	-	LDO	PTHR10196
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3110
TreeFam	1	0.960	-	-
	13	12.940