DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3534 and Xylb

DIOPT Version :9

Sequence 1:	NP_650582.1	Gene:	CG3534 / 42047	FlyBaseID:	FBgn0038463	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_001028381.1	Gene:	Xylb / 102448	MGIID:	2142985	Length:	551	Species:	Mus musculus

Alignment Length:	554	Identity:	243/554 - (43%)
Similarity:	351/554 - (63%)	Gaps:	27/554 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GPPKQL-----KRTFLGFDLSTQKLKAVLLGSSLEVVAAAEVKFDTDLPEFRTTGGANAGSIKNE 61
            |.|:.|     :|..||:|.|||::|.|.:.:.|.|.....|.||.|||||.|.||.:....:..
Mouse    11 GTPRALAERAGRRCCLGWDFSTQQVKVVAVDAELNVFYEDSVHFDRDLPEFGTQGGVHVHKDRLT 75

  Fly    62 YFVQPVMWVKAMDIVLDRLVMQQADLSTVAAISGSGQQHGSLYWSKHGINTLQNLDSEKFLHAQI 126
            .....:|||:|:|::|.::.....|.|.|.|:||:||||||:||.......|.:|.....||.|:
Mouse    76 VTSPVLMWVQALDLILGKMKSSGFDFSQVLALSGAGQQHGSVYWKTGASLALSSLSPALPLHQQL 140

  Fly   127 DDSAFVVNRTPIWMDATTTKQCLEMEMAVGGKLNMVELTGSKCYERFTGPQIRKIYQQRCHAYEE 191
             .|.|.::..|||||::||.||.::|.||||...:..||||:.||||||.||.|::|:...||..
Mouse   141 -QSCFSISDCPIWMDSSTTAQCHQLEAAVGGAQALSCLTGSRAYERFTGNQIAKLFQKNPEAYSH 204

  Fly   192 ANRISLVSSFISSLFLGSVAPIDFSDGSGMNLLDIRKKNWSKECLNVCAPDLDKRLDIPVSPNSI 256
            :.||||||||.:|||||..:|||:|||||||||.|::|.||:.||:||||.|:::|..||...|:
Mouse   205 SERISLVSSFAASLFLGGYSPIDYSDGSGMNLLQIQEKVWSQACLDVCAPHLEEKLGSPVPSCSV 269

  Fly   257 LGNVSPYFVERFSFSPDCKVAASTGDNPSALSGMLVGSSWLTISMGTSDTLMMSLKEPLNWEEGH 321
            :|.:|.|:|:|:.|.|.|||.|.:||||::|:||.:....:.:|:||||||.:.|::|:...|||
Mouse   270 VGTISSYYVQRYGFPPGCKVVAFSGDNPASLAGMRLEEGDIAVSLGTSDTLFLWLQKPMPALEGH 334

  Fly   322 ILCHPTETEEFMGLLCFRNASLVREEMNKKTTGGDWDKFNEYLDSTPRGNFGNMAVHFNDMEIIP 386
            |.|:|.:.:.:|.||||:|.||:||::..::....|:||::.|.||..||.||:..:|:.|||.|
Mouse   335 IFCNPVDPQHYMALLCFKNGSLMREKIRDESASCSWNKFSKALKSTAMGNNGNLGFYFDVMEITP 399

  Fly   387 KAQGILRWNRE-MDPSSPDAARGVIKFSSPQIEIRALVEGQMLHHRAVAEDLGYKFGPETQILVT 450
            :..|..|:|.| |:.|:         |.. .:|||||:|||.:..|..||.|||:..|:|:||.|
Mouse   400 EIIGRHRFNAENMEVSA---------FPG-DVEIRALIEGQFMAKRIHAEGLGYRVMPKTKILAT 454

  Fly   451 GGASVNKSILQTIADVFNAPVHIQDEGFEAALLGAAYRSAYALYLQEAGDGVTPLCYRDYILSLT 515
            ||||.||.|||.:||||.|||::.|. ..:|.:|:|||:.:.|      .|.|.:.:.:.:.|
Mouse   455 GGASHNKDILQVLADVFGAPVYVIDT-TSSACVGSAYRAFHGL------AGGTGVAFSEVVKS-- 510

  Fly   516 SNKLSLVCEPHKDSEEIYAPMLQRYREM-ARVLS 548
            :.:.||...|:..:.::||.:|.||..: .|:||
Mouse   511 APQPSLAATPNPGASQVYAALLPRYSALEQRILS 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3534	NP_650582.1	FGGY_D-XK_euk	10..491	CDD:212660	224/481 (47%)
		PLN02669	11..546	CDD:178274	236/536 (44%)
		NBD_sugar-kinase_HSP70_actin	<447..545	CDD:302596	37/98 (38%)
Xylb	NP_001028381.1	FGGY_D-XK_euk	24..494	CDD:212660	224/481 (47%)
Xylb	NP_001028381.1	PLN02669	26..549	CDD:178274	239/539 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833646
Domainoid	1	1.000	185	1.000	Domainoid score	I3382
eggNOG	1	0.900	-	-		E1_COG1070
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3746
Inparanoid	1	1.050	441	1.000	Inparanoid score	I1643
Isobase	1	0.950	-	0	Normalized mean entropy	S1469
OMA	1	1.010	-	-		QHG56396
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004391
OrthoInspector	1	1.000	-	-		otm43432
orthoMCL	1	0.900	-	-		OOG6_104017
Panther	1	1.100	-	-	LDO	PTHR10196
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1675
SonicParanoid	1	1.000	-	-		X3110
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740