DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment EMC2A and EMC2

DIOPT Version :9

Sequence 1:	NP_001262652.1	Gene:	EMC2A / 42046	FlyBaseID:	FBgn0038462	Length:	282	Species:	Drosophila melanogaster
Sequence 2:	NP_001316422.1	Gene:	EMC2 / 9694	HGNCID:	28963	Length:	306	Species:	Homo sapiens

Alignment Length:	290	Identity:	128/290 - (44%)
Similarity:	196/290 - (67%)	Gaps:	19/290 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 MSWSDVRDQFRTWREETGRHSEEVVQLWVAVLEDKVHKTGNERH---------LILEQVIIAALD 63
            ::|.::||:.|.||||..|:||::|::...::.:...|.|::..         :|.|||:|||||
Human    10 VTWEEMRDKMRKWREENSRNSEQIVEVGEELINEYASKLGDDIFFPLYVYLVWIIYEQVMIAALD 74

  Fly    64 TARFDIATKCTKQLSLEFPGSLRVMKFKAMRYEALEQYDEADEVLDAIIAKDETNAAPRKRKIAI 128
            ..|.|:|..|.::|..:||||.||.:...||:||:|:||:|.::.|.|:.:|.||.|.|||||||
Human    75 YGRDDLALFCLQELRRQFPGSHRVKRLTGMRFEAMERYDDAIQLYDRILQEDPTNTAARKRKIAI 139

  Fly   129 LKARGRRLEAIKELNEYLKKFMSDQEAWHELCNMYLAEGEFGKAAFCMEEVLLHNPHSHLIHQRL 193
            .||:|:.:|||:||||||::|:.||||||||..:|:.|.::.|||||:||:::.|||:||..|:.
Human   140 RKAQGKNVEAIRELNEYLEQFVGDQEAWHELAELYINEHDYAKAAFCLEELMMTNPHNHLYCQQY 204

  Fly   194 AEIRYTMGGVENMESARTYYSQALKLNPHNLRALYGIYLCCNHL-DNSRAVSSKRKELQKLSQWA 257
            ||::||.||:||:|.:|.|::||||||..|:|||:|:|:..:|: .|.:|.:..:|:..|.:.||
Human   205 AEVKYTQGGLENLELSRKYFAQALKLNNRNMRALFGLYMSASHIASNPKASAKTKKDNMKYASWA 269

  Fly   258 LEQL---------LTKQTIVPLEAAFGNLE 278
            ..|:         ..|:|...|:|....||
Human   270 ASQINRAYQFAGRSKKETKYSLKAVEDMLE 299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EMC2A	NP_001262652.1	TPR repeat	86..113	CDD:276809	12/26 (46%)
		TPR_11	154..221	CDD:290150	37/66 (56%)
		TPR repeat	154..181	CDD:276809	15/26 (58%)
		TPR repeat	186..219	CDD:276809	17/32 (53%)
EMC2	NP_001316422.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160329
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3060
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8785
Inparanoid	1	1.050	269	1.000	Inparanoid score	I3020
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55498
OrthoDB	1	1.010	-	-		D465703at33208
OrthoFinder	1	1.000	-	-		FOG0003504
OrthoInspector	1	1.000	-	-		otm41303
orthoMCL	1	0.900	-	-		OOG6_102350
Panther	1	1.100	-	-	LDO	PTHR12760
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R859
SonicParanoid	1	1.000	-	-		X2876
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800