DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment EMC2A and emc-2

DIOPT Version :9

Sequence 1:	NP_001262652.1	Gene:	EMC2A / 42046	FlyBaseID:	FBgn0038462	Length:	282	Species:	Drosophila melanogaster
Sequence 2:	NP_001254028.1	Gene:	emc-2 / 173509	WormBaseID:	WBGene00021973	Length:	294	Species:	Caenorhabditis elegans

Alignment Length:	280	Identity:	111/280 - (39%)
Similarity:	178/280 - (63%)	Gaps:	11/280 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DYEKMSWSDVRDQFRTWREETGRHSEEVVQLWVAVLEDKVHKTGNERHLILEQVIIAALDTARFD 68
            ::.::|:.:.|...:.|||...|.|:|||::|..|:.......|:|:..:||||.|||||.||.|
Worm     5 EWTQVSYDEGRQALKKWRECGVRRSDEVVEIWEHVISRSPASLGDEQWAVLEQVCIAALDAARVD 69

  Fly    69 IATKCTKQLSLEFPGSLRVMKFKAMRYEALEQYDEADEVLDAIIAKDETNAAPRKRKIAILKARG 133
            :|..|..||..:||.|.||:|.|||:.|:.|.|.:|.::.:.::..:..|.:.||||:|:|.|:|
Worm    70 LAQDCIDQLHAQFPKSNRVLKLKAMQLESTEHYQKALDIYERLVEDEPNNNSFRKRKVAVLLAQG 134

  Fly   134 RRLEAIKELNEYLKKFMSDQEAWHELCNMYLAEGEFGKAAFCMEEVLLHNPHSHLIHQRLAEIRY 198
            :||:||:.:|:|||.|::|.|||.:|..::|.|.:..||..|:||.:|.:|.:.:..:|||::||
Worm   135 KRLDAIRAINDYLKIFLNDPEAWLQLSELFLLENDVAKAVHCLEECVLISPLNSMYFRRLADLRY 199

  Fly   199 TMGGVENMESARTYYSQALKLNPHNLRALYGIYLCCNHLDNSRAVSSKRKELQKLSQWALEQLLT 263
            |.||.||:|.||:||.:|||:||.:||:.|||.|..|.:..:...::::|:....:..|::.|:.
Worm   200 TQGGAENVELARSYYERALKINPTDLRSQYGILLSNNLIAATTKNATEKKKAGAAAVDAIDNLVN 264

  Fly   264 K-QTIVPLEAAFGNLEIKSN 282
            : |.|.|          |||
Worm   265 RYQKISP----------KSN 274

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EMC2A	NP_001262652.1	TPR repeat	86..113	CDD:276809	10/26 (38%)
		TPR_11	154..221	CDD:290150	31/66 (47%)
		TPR repeat	154..181	CDD:276809	11/26 (42%)
		TPR repeat	186..219	CDD:276809	17/32 (53%)
emc-2	NP_001254028.1	PEP_TPR_lipo	<61..>240	CDD:274350	83/178 (47%)
		TPR repeat	87..114	CDD:276809	10/26 (38%)
		TPR repeat	153..183	CDD:276809	12/29 (41%)
		TPR repeat	188..219	CDD:276809	16/30 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167770
Domainoid	1	1.000	128	1.000	Domainoid score	I3302
eggNOG	1	0.900	-	-		E1_KOG3060
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8785
Inparanoid	1	1.050	213	1.000	Inparanoid score	I2349
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55498
OrthoDB	1	1.010	-	-		D465703at33208
OrthoFinder	1	1.000	-	-		FOG0003504
OrthoInspector	1	1.000	-	-		otm14381
orthoMCL	1	0.900	-	-		OOG6_102350
Panther	1	1.100	-	-	LDO	PTHR12760
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R859
SonicParanoid	1	1.000	-	-		X2876
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800