Protein Alignment EMC2B and EMC2

DIOPT Version :10

• Sequence 1: NP_650580.1
• Gene: EMC2B / 42045
• FlyBaseID: FBgn0038461
• Length: 282
• Species: Drosophila melanogaster
• Sequence 2: NP_012621.1
• Gene: EMC2 / 853550
• SGDID: S000003848
• Length: 292
• Species: Saccharomyces cerevisiae
• Alignment Length: 263
• Identity: 62/263 - (23%)
• Similarity: 102/263 - (38%)
• Gaps: 65/263 - (24%)

  Fly    12 DVRDQFRTWREETGRHSEEVVQLWVAVLEDKVHKTGNERHLI--LEQVIIAALDTARFDIATKCT 74
            |.:..:.|.|:..|.:|.::|.:...:|:    ..||::..|  ||.::...|:.
Yeast    69 DAQVVYNTLRDRLGENSYKMVIMKATLLQ----INGNDKGAIEYLENLLNDDLEY---------- 119

  Fly    75 KQLALEFPGSLRVMKFKAMRYEALEQYDEADEVLDAIIAKDETNAAPRKRKIAILKARGRRL--- 136
                                        |.|.|....|||          |:..:|...:.|
Yeast   120 ----------------------------ETDFVTYVSIAK----------KLIAIKTTSKNLSQE 146

  Fly   137 EAIKELNEYLKKFMSDQEAWHELCNMYLAEGEFGKAAFCMEEVLLHNPHSHLIHQRLAEIRYTMG 201
            ..:||:.....||..|.|.|.....:|...|:|.||.:|:|:||...|.::....||:|..|...
Yeast   147 SVLKEVVALTDKFPLDAELWWYASEIYFEMGQFEKACYCLEQVLCITPFNYACFGRLSETLYYEA 211

  Fly   202 GVENMESARTYYSQALKLNPHNLRA--LYGIYLCCNHLDN--SRAVS-SKRKELQKLSQWALEQL 261
            .....::......:|||   :.||:  |..:||....|.|  ||.:. :|:.:|.|||...|:::
Yeast   212 LRSKKQTKTELLEKALK---NALRSVELSELYLKGWALVNIISRELGRNKQNDLIKLSASKLKEI 273

  Fly   262 LTK 264
            ..|
Yeast   274 SAK 276

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EMC2B	NP_650580.1	Spy	49..>243	CDD:443119	46/202 (23%)
		TPR repeat	86..113	CDD:276809	3/26 (12%)
		TPR repeat	154..181	CDD:276809	10/26 (38%)
		TPR repeat	186..219	CDD:276809	6/32 (19%)
EMC2	NP_012621.1	NrfG	160..>246	CDD:443378	25/88 (28%)
		TPR repeat	163..191	CDD:276809	10/27 (37%)
		TPR repeat	196..236	CDD:276809	9/42 (21%)