DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment EMC2B and Emc2

DIOPT Version :9

Sequence 1:	NP_001262651.1	Gene:	EMC2B / 42045	FlyBaseID:	FBgn0038461	Length:	282	Species:	Drosophila melanogaster
Sequence 2:	NP_080012.1	Gene:	Emc2 / 66736	MGIID:	1913986	Length:	297	Species:	Mus musculus

Alignment Length:	281	Identity:	128/281 - (45%)
Similarity:	196/281 - (69%)	Gaps:	10/281 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 MSWSDVRDQFRTWREETGRHSEEVVQLWVAVLEDKVHKTGNERHLILEQVIIAALDTARFDIATK 72
            ::|.::||:.|.||||..|:||:::::...::.|...|.|::..:|.|||:|||||..|.|:|..
Mouse    10 VTWEEMRDKMRKWREENSRNSEQIMEVGEELINDYASKLGDDIWIIYEQVMIAALDYGRDDLALF 74

  Fly    73 CTKQLALEFPGSLRVMKFKAMRYEALEQYDEADEVLDAIIAKDETNAAPRKRKIAILKARGRRLE 137
            |.::|..:||||.||.:...||:||:|:||:|.::.|.|:.:|.||.|.|||||||.||:|:.:|
Mouse    75 CLQELRRQFPGSHRVKRLTGMRFEAMERYDDAIQLYDRILQEDPTNTAARKRKIAIRKAQGKTVE 139

  Fly   138 AIKELNEYLKKFMSDQEAWHELCNMYLAEGEFGKAAFCMEEVLLHNPHSHLIHQRLAEIRYTMGG 202
            ||:||||||::|:.||||||||..:|:.|.::.|||||:||:::.|||:||..|:.||::||.||
Mouse   140 AIRELNEYLEQFVGDQEAWHELAELYINEHDYAKAAFCLEELMMTNPHNHLYCQQYAEVKYTQGG 204

  Fly   203 VENMESARTYYSQALKLNPHNLRALYGIYLCCNHL-DNSRAVSSKRKELQKLSQWALEQL----- 261
            :||:|.:|.|::||||||..|:|||:|:|:..:|: .|.:|.:..:|:..|.:.||..|:
Mouse   205 LENLELSRKYFAQALKLNNRNMRALFGLYMSASHIASNPKASAKMKKDNIKYASWAANQINRAYQ 269

  Fly   262 ----LTKQTIVPLEAAFGNLE 278
                ..|:|...|:|....||
Mouse   270 FAGRSKKETKYSLKAVEDMLE 290

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EMC2B	NP_001262651.1	TPR repeat	86..113	CDD:276809	12/26 (46%)
		TPR_11	154..221	CDD:290150	37/66 (56%)
		TPR repeat	154..181	CDD:276809	15/26 (58%)
		TPR repeat	186..219	CDD:276809	17/32 (53%)
Emc2	NP_080012.1	TPR_16	62..121	CDD:290168	27/58 (47%)
		TPR 1. /evidence=ECO:0000255	87..120		13/32 (41%)
		TPR_19	99..164	CDD:291240	39/64 (61%)
		TPR repeat	120..150	CDD:276809	21/29 (72%)
		TPR 2. /evidence=ECO:0000255	155..188		18/32 (56%)
		TPR repeat	155..182	CDD:276809	16/26 (62%)
		TPR_11	156..222	CDD:290150	36/65 (55%)
		TPR repeat	188..221	CDD:276809	17/32 (53%)
		TPR 3. /evidence=ECO:0000255	192..225		18/32 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850682
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3060
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8785
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3021
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55498
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003504
OrthoInspector	1	1.000	-	-		otm43361
orthoMCL	1	0.900	-	-		OOG6_102350
Panther	1	1.100	-	-	O	PTHR12760
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2876
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.760