DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment EMC2B and oca3

DIOPT Version :9

Sequence 1:	NP_001262651.1	Gene:	EMC2B / 42045	FlyBaseID:	FBgn0038461	Length:	282	Species:	Drosophila melanogaster
Sequence 2:	NP_595921.2	Gene:	oca3 / 2539872	PomBaseID:	SPBC15C4.01c	Length:	282	Species:	Schizosaccharomyces pombe

Alignment Length:	225	Identity:	65/225 - (28%)
Similarity:	112/225 - (49%)	Gaps:	15/225 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 KVHKTGNERHLILEQVIIAALDTARFDIATKCTKQLALEFPGSLRVMKFKAMRYEALEQYDEADE 106
            |:.|..:|...:.::|.||||.|....:|.||..:|...|..|.||.....|..||.....:|..
pombe    28 KLGKYKDEIWDVYQKVFIAALTTGETVLAKKCWNRLNDRFHKSPRVEGLYGMFLEATASEKDAMS 92

  Fly   107 VLDAIIAKDETNAAPRKRKIAILKARGRRLEAIKELNEYLKKFMSDQEAWHELCNMYLAEGEFGK 171
            ..::.:::|.|:....|||:|:|::.|:..|.|:.|..||..|.:|.|||.||.::|::...|..
pombe    93 YYNSKLSEDPTHTVIYKRKLALLRSMGQTKECIQGLINYLDTFYNDLEAWAELADIYVSVEAFES 157

  Fly   172 AAFCMEEVLLHNPHSHLIHQRLAEIRYTM--GGVENMESARTYYSQALKLNPHNLRALYGIYLCC 234
            |.||.||::|..|....:..||.::.:.:  ....|...:..:|.:::::........:||..||
pombe   158 AIFCYEEMVLLQPFEPRLFARLGDLYFVLAQSNATNYWFSLKHYCRSVEICEEYFHGWFGISKCC 222

  Fly   235 NHLDNSRAVSSKRKELQKLSQWALEQLLTK 264
                         ::|.:||:..|::||:|
pombe   223 -------------QQLLELSRTELKRLLSK 239

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EMC2B	NP_001262651.1	TPR repeat	86..113	CDD:276809	6/26 (23%)
		TPR_11	154..221	CDD:290150	18/68 (26%)
		TPR repeat	154..181	CDD:276809	12/26 (46%)
		TPR repeat	186..219	CDD:276809	4/34 (12%)
oca3	NP_595921.2	TPR repeat	107..133	CDD:276809	10/25 (40%)
		TPR_11	140..207	CDD:290150	18/66 (27%)
		TPR repeat	140..167	CDD:276809	12/26 (46%)
		TPR repeat	172..207	CDD:276809	4/34 (12%)
		TPR repeat	212..238	CDD:276809	9/38 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	96	1.000	Domainoid score	I1917
eggNOG	1	0.900	-	-		E1_KOG3060
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8785
Inparanoid	1	1.050	96	1.000	Inparanoid score	I1695
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003504
OrthoInspector	1	1.000	-	-		otm47245
orthoMCL	1	0.900	-	-		OOG6_102350
Panther	1	1.100	-	-	O	PTHR12760
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2876
TreeFam	1	0.960	-	-
	12	11.820