DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AhcyL2 and ahcyl2a

DIOPT Version :9

Sequence 1:	NP_996221.1	Gene:	AhcyL2 / 42043	FlyBaseID:	FBgn0015011	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	XP_005170753.2	Gene:	ahcyl2a / 791167	ZFINID:	ZDB-GENE-070112-1522	Length:	516	Species:	Danio rerio

Alignment Length:	492	Identity:	321/492 - (65%)
Similarity:	390/492 - (79%)	Gaps:	12/492 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PETTFADLSLADKTAVKKSSIEARRFSDVSTCSFSSTCFTGSSDEED----VSPKDNHQRNSAGG 65
            ||.|....:...||..:..|   ...|..||.|.||    |.||.||    |||:|..:.||.|.
Zfish    31 PEQTREFDNRLTKTGRRSLS---HSLSHSSTDSNSS----GGSDAEDPENEVSPRDKQRMNSKGN 88

  Fly    66 TDFCVKSISKSAFGRREIEIAESEMPGIMTLRKRAKDEKPLKGANIVGCTHVNAQSAVLIETLVQ 130
            .|||:|:|..:.||||:||:||.||..:|.|||.|:.||||.||.|||||||.||:|||.|||..
Zfish    89 KDFCIKNIKLADFGRRQIELAEDEMTALMALRKAAQGEKPLAGAKIVGCTHVTAQTAVLFETLSG 153

  Fly   131 LGATVRWAACNIYSTQNAVAAALAEAGIPIFAWRGETEEEFWWCLDRAIYSDGWQPNLILDDGGD 195
            |||..||||||||||||.|||||||...|:|||:||:|::||||:||.:..:||:||:|||||||
Zfish   154 LGAQCRWAACNIYSTQNEVAAALAERDFPVFAWKGESEDDFWWCIDRCVNVEGWEPNMILDDGGD 218

  Fly   196 ATHLMLKKYPDYFKAIRGIVEESVTGVHRLYMLSKGGKLTVPAINVNDSVTKNKFDTFYTCRDSI 260
            .||.:.||||..||.::||||||:||:|||:.|||.|||.||||||||||||.|||..|.||:||
Zfish   219 MTHWIYKKYPHIFKKVKGIVEESITGIHRLHHLSKAGKLCVPAINVNDSVTKQKFDNLYCCRESI 283

  Fly   261 LDSLKRTTDIMFGGKQVVICGYGDVGKGCAQSLKGQGCIVYVTEVDPICALQAAMDGFRVVRLNE 325
            |||||:|.||||||||||:||||:|||||:.:||..|.||||||:||||||||.|||||:.:|::
Zfish   284 LDSLKKTADIMFGGKQVVVCGYGEVGKGCSAALKAMGSIVYVTEIDPICALQACMDGFRLTKLSD 348

  Fly   326 VIRTVDVVVTATGNKNVITRDHMNRMKNGCILCNMGHSCSEIDVNGLHTPELTWERVRSQVDHIR 390
            |:|.||:|:|.||||||:.|:||:.|||||::||||.|.:||:|:.|.||:|||:.||:|||||.
Zfish   349 VVRQVDMVITCTGNKNVVVREHMDVMKNGCVVCNMGRSNTEINVSALKTPDLTWQHVRAQVDHII 413

  Fly   391 WPDGRMIILLAEGRLVNLSCSTISSFVVSVASSTQALALIELFSAP-GRYKSDVYLLPKKMDEYV 454
            ||||:.:|||||||::|||.||:..:|:|:.::||||||||||:|| ||||.||||||||:||||
Zfish   414 WPDGKRMILLAEGRVLNLSSSTVPIYVLSITATTQALALIELFNAPEGRYKQDVYLLPKKLDEYV 478

  Fly   455 ASLHLATFDAHLTELTDEQSKFMGLNKAGPFKANYYR 491
            |||||.|||||||||||:|:|:|||:|.||||.||||
Zfish   479 ASLHLQTFDAHLTELTDDQAKYMGLSKNGPFKPNYYR 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AhcyL2	NP_996221.1	PRK05476	63..486	CDD:235488	292/423 (69%)
AhcyL2	NP_996221.1	AdoHcyase	67..491	CDD:283003	295/424 (70%)
ahcyl2a	XP_005170753.2	PRK05476	88..510	CDD:235488	291/421 (69%)
ahcyl2a	XP_005170753.2	AdoHcyase	90..515	CDD:283003	295/424 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581631
Domainoid	1	1.000	282	1.000	Domainoid score	I1614
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D207688at33208
OrthoFinder	1	1.000	-	-		FOG0003070
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104147
Panther	1	1.100	-	-	O	PTHR23420
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.850