DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AhcyL2 and Ahcyl2

DIOPT Version :9

Sequence 1:	NP_996221.1	Gene:	AhcyL2 / 42043	FlyBaseID:	FBgn0015011	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_067389.5	Gene:	Ahcyl2 / 74340	MGIID:	1921590	Length:	613	Species:	Mus musculus

Alignment Length:	501	Identity:	344/501 - (68%)
Similarity:	411/501 - (82%)	Gaps:	12/501 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAKMPETTFADLSLADK--------TAVKKSSIEARRFSDVSTCSFSSTC-FTGSSDEEDVSPKD 56
            :.:.|.|....:..||:        |.:.:.|: :|..|..||.|:||.. :|.|||:| .||:|
Mouse   114 VTEAPRTVKKQIQFADQKQEFNKRPTKIGRRSL-SRSISQSSTDSYSSAASYTDSSDDE-TSPRD 176

  Fly    57 NHQRNSAGGTDFCVKSISKSAFGRREIEIAESEMPGIMTLRKRAKDEKPLKGANIVGCTHVNAQS 121
            ..|:||.|.:|||||:|.::.||||||||||.|||.:|.|||||:.||||.||.||||||:.||:
Mouse   177 KQQKNSKGSSDFCVKNIKQAEFGRREIEIAEQEMPALMALRKRAQGEKPLAGAKIVGCTHITAQT 241

  Fly   122 AVLIETLVQLGATVRWAACNIYSTQNAVAAALAEAGIPIFAWRGETEEEFWWCLDRAIYSDGWQP 186
            |||:|||..|||..||||||||||.|.|||||||:|.|:|||:||:|::||||:||.:..:||||
Mouse   242 AVLMETLGALGAQCRWAACNIYSTLNEVAAALAESGFPVFAWKGESEDDFWWCIDRCVNVEGWQP 306

  Fly   187 NLILDDGGDATHLMLKKYPDYFKAIRGIVEESVTGVHRLYMLSKGGKLTVPAINVNDSVTKNKFD 251
            |:|||||||.||.:.||||:.||.|:||||||||||||||.|||.|||.|||:||||||||.|||
Mouse   307 NMILDDGGDLTHWIYKKYPNMFKKIKGIVEESVTGVHRLYQLSKAGKLCVPAMNVNDSVTKQKFD 371

  Fly   252 TFYTCRDSILDSLKRTTDIMFGGKQVVICGYGDVGKGCAQSLKGQGCIVYVTEVDPICALQAAMD 316
            ..|.||:||||.||||||:||||||||:||||:|||||..:||..|.||||||:||||||||.||
Mouse   372 NLYCCRESILDGLKRTTDMMFGGKQVVVCGYGEVGKGCCAALKAMGSIVYVTEIDPICALQACMD 436

  Fly   317 GFRVVRLNEVIRTVDVVVTATGNKNVITRDHMNRMKNGCILCNMGHSCSEIDVNGLHTPELTWER 381
            |||:|:||||||.||:|:|.||||||:||:|::||||.||:||||||.:||||..|.||||||||
Mouse   437 GFRLVKLNEVIRQVDIVITCTGNKNVVTREHLDRMKNSCIVCNMGHSNTEIDVASLRTPELTWER 501

  Fly   382 VRSQVDHIRWPDGRMIILLAEGRLVNLSCSTISSFVVSVASSTQALALIELFSAP-GRYKSDVYL 445
            |||||||:.||||:.|:|||||||:||||||:.:||:|:.::|||||||||::|| ||||.||||
Mouse   502 VRSQVDHVIWPDGKRIVLLAEGRLLNLSCSTVPTFVLSITATTQALALIELYNAPEGRYKQDVYL 566

  Fly   446 LPKKMDEYVASLHLATFDAHLTELTDEQSKFMGLNKAGPFKANYYR 491
            ||||||||||||||.|||||||||||||:|::||||.||||.||||
Mouse   567 LPKKMDEYVASLHLPTFDAHLTELTDEQAKYLGLNKNGPFKPNYYR 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AhcyL2	NP_996221.1	PRK05476	63..486	CDD:235488	314/423 (74%)
AhcyL2	NP_996221.1	AdoHcyase	67..491	CDD:283003	317/424 (75%)
Ahcyl2	NP_067389.5	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..186		25/73 (34%)
		LISN domain, inhibits interaction with ITPR1. /evidence=ECO:0000250\|UniProtKB:Q96HN2	2..111
		AdoHcyase	187..612	CDD:310083	317/424 (75%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837867
Domainoid	1	1.000	282	1.000	Domainoid score	I1644
eggNOG	1	0.900	-	-		E1_COG0499
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H69337
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D207688at33208
OrthoFinder	1	1.000	-	-		FOG0003070
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104147
Panther	1	1.100	-	-	O	PTHR23420
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.710