DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AhcyL2 and ahcyl2b

DIOPT Version :9

Sequence 1:	NP_996221.1	Gene:	AhcyL2 / 42043	FlyBaseID:	FBgn0015011	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_958497.1	Gene:	ahcyl2b / 394240	ZFINID:	ZDB-GENE-040115-5	Length:	591	Species:	Danio rerio

Alignment Length:	494	Identity:	341/494 - (69%)
Similarity:	408/494 - (82%)	Gaps:	7/494 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KMPETTFADLSL---ADKTAVKKSSIEARRFSDVSTCSFSSTC-FTGSSDEEDVSPKDNHQRNSA 63
            :|.:..|||...   ...|.:.:.|: :|..|..||.|:||.. :|.|||:| .||:|..|:||.
Zfish    99 RMKKIQFADQKQEFNKRPTKIGRRSL-SRSISQSSTDSYSSAASYTDSSDDE-TSPRDKQQKNSK 161

  Fly    64 GGTDFCVKSISKSAFGRREIEIAESEMPGIMTLRKRAKDEKPLKGANIVGCTHVNAQSAVLIETL 128
            |..|||:|:|.::.||||||||||.|||.:|.|||||:.||||.||.||||||:.||:|||:|||
Zfish   162 GSGDFCIKNIKQADFGRREIEIAEQEMPALMALRKRAQGEKPLAGAKIVGCTHITAQTAVLMETL 226

  Fly   129 VQLGATVRWAACNIYSTQNAVAAALAEAGIPIFAWRGETEEEFWWCLDRAIYSDGWQPNLILDDG 193
            ..|||..||||||||||||.|||||||.|..:|||:||:|::||||:||.:..:|||||:|||||
Zfish   227 SALGAQCRWAACNIYSTQNEVAAALAEGGFSVFAWKGESEDDFWWCIDRCVNVEGWQPNMILDDG 291

  Fly   194 GDATHLMLKKYPDYFKAIRGIVEESVTGVHRLYMLSKGGKLTVPAINVNDSVTKNKFDTFYTCRD 258
            ||.||.:.||||:.||.|:||||||||||||||.|||.|||.|||:||||||||.|||..|.||:
Zfish   292 GDLTHWIYKKYPNMFKKIKGIVEESVTGVHRLYQLSKAGKLCVPAMNVNDSVTKQKFDNLYCCRE 356

  Fly   259 SILDSLKRTTDIMFGGKQVVICGYGDVGKGCAQSLKGQGCIVYVTEVDPICALQAAMDGFRVVRL 323
            ||||.||||||:||||||||:||||:|||||:.:||..|.||||||:||||||||.|||||:|:|
Zfish   357 SILDGLKRTTDVMFGGKQVVVCGYGEVGKGCSAALKAMGSIVYVTEIDPICALQACMDGFRLVKL 421

  Fly   324 NEVIRTVDVVVTATGNKNVITRDHMNRMKNGCILCNMGHSCSEIDVNGLHTPELTWERVRSQVDH 388
            :||||.||:|:|.||||||:.|::|:|||||||:||||||.:||||..|.|||||||||||||||
Zfish   422 SEVIRQVDIVITCTGNKNVVVREYMDRMKNGCIVCNMGHSNTEIDVASLRTPELTWERVRSQVDH 486

  Fly   389 IRWPDGRMIILLAEGRLVNLSCSTISSFVVSVASSTQALALIELFSAP-GRYKSDVYLLPKKMDE 452
            :.||||:.|:|||||||:||||||:.:||:|:.::|||||||||::|| ||||.|||||||||||
Zfish   487 VIWPDGKRIVLLAEGRLLNLSCSTVPTFVLSITATTQALALIELYNAPEGRYKQDVYLLPKKMDE 551

  Fly   453 YVASLHLATFDAHLTELTDEQSKFMGLNKAGPFKANYYR 491
            |||||||.|||||||||:|||:|::||||.||||.||||
Zfish   552 YVASLHLPTFDAHLTELSDEQAKYLGLNKNGPFKPNYYR 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AhcyL2	NP_996221.1	PRK05476	63..486	CDD:235488	311/423 (74%)
AhcyL2	NP_996221.1	AdoHcyase	67..491	CDD:283003	314/424 (74%)
ahcyl2b	NP_958497.1	AdoHcyase	165..590	CDD:283003	314/424 (74%)
ahcyl2b	NP_958497.1	PRK05476	165..585	CDD:235488	310/419 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581632
Domainoid	1	1.000	282	1.000	Domainoid score	I1614
eggNOG	1	0.900	-	-		E1_COG0499
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H69337
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D207688at33208
OrthoFinder	1	1.000	-	-		FOG0003070
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104147
Panther	1	1.100	-	-	O	PTHR23420
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.710