DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AhcyL2 and Ahcyl1

DIOPT Version :9

Sequence 1:	NP_996221.1	Gene:	AhcyL2 / 42043	FlyBaseID:	FBgn0015011	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	XP_008759627.2	Gene:	Ahcyl1 / 362013	RGDID:	1309768	Length:	530	Species:	Rattus norvegicus

Alignment Length:	500	Identity:	342/500 - (68%)
Similarity:	408/500 - (81%)	Gaps:	13/500 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAKMP--ETTFAD-----LSLADKTAVKKSSIEARRFSDVSTCSFSSTC-FTGSSDEEDVSPKDN 57
            :.|.|  :..|||     .....||..:..|   |..|..||.|:||.. :|.|||:| |||::.
  Rat    34 VTKAPKKQIQFADDMQEFTKFPTKTGRRSLS---RSISQSSTDSYSSAASYTDSSDDE-VSPREK 94

  Fly    58 HQRNSAGGTDFCVKSISKSAFGRREIEIAESEMPGIMTLRKRAKDEKPLKGANIVGCTHVNAQSA 122
            .|.||.|.::||||:|.::.||||||||||.:|..:::|||||:.||||.||.||||||:.||:|
  Rat    95 QQTNSKGSSNFCVKNIKQAEFGRREIEIAEQDMSALISLRKRAQGEKPLAGAKIVGCTHITAQTA 159

  Fly   123 VLIETLVQLGATVRWAACNIYSTQNAVAAALAEAGIPIFAWRGETEEEFWWCLDRAIYSDGWQPN 187
            ||||||..|||..||:|||||||||.|||||||||:.:|||:||:|::||||:||.:..||||.|
  Rat   160 VLIETLCALGAQCRWSACNIYSTQNEVAAALAEAGVAVFAWKGESEDDFWWCIDRCVNMDGWQAN 224

  Fly   188 LILDDGGDATHLMLKKYPDYFKAIRGIVEESVTGVHRLYMLSKGGKLTVPAINVNDSVTKNKFDT 252
            :|||||||.||.:.||||:.||.||||||||||||||||.|||.|||.|||:||||||||.|||.
  Rat   225 MILDDGGDLTHWVYKKYPNVFKKIRGIVEESVTGVHRLYQLSKAGKLCVPAMNVNDSVTKQKFDN 289

  Fly   253 FYTCRDSILDSLKRTTDIMFGGKQVVICGYGDVGKGCAQSLKGQGCIVYVTEVDPICALQAAMDG 317
            .|.||:||||.||||||:||||||||:||||:|||||..:||..|.|||:||:||||||||.|||
  Rat   290 LYCCRESILDGLKRTTDVMFGGKQVVVCGYGEVGKGCCAALKALGAIVYITEIDPICALQACMDG 354

  Fly   318 FRVVRLNEVIRTVDVVVTATGNKNVITRDHMNRMKNGCILCNMGHSCSEIDVNGLHTPELTWERV 382
            ||||:||||||.||||:|.||||||:||:|::||||.||:||||||.:||||..|.|||||||||
  Rat   355 FRVVKLNEVIRQVDVVITCTGNKNVVTREHLDRMKNSCIVCNMGHSNTEIDVTSLRTPELTWERV 419

  Fly   383 RSQVDHIRWPDGRMIILLAEGRLVNLSCSTISSFVVSVASSTQALALIELFSAP-GRYKSDVYLL 446
            ||||||:.||||:.::|||||||:||||||:.:||:|:.::|||||||||::|| ||||.|||||
  Rat   420 RSQVDHVIWPDGKRVVLLAEGRLLNLSCSTVPTFVLSITATTQALALIELYNAPEGRYKQDVYLL 484

  Fly   447 PKKMDEYVASLHLATFDAHLTELTDEQSKFMGLNKAGPFKANYYR 491
            |||||||||||||.:||||||||||:|:|::||||.||||.||||
  Rat   485 PKKMDEYVASLHLPSFDAHLTELTDDQAKYLGLNKNGPFKPNYYR 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AhcyL2	NP_996221.1	PRK05476	63..486	CDD:235488	310/423 (73%)
AhcyL2	NP_996221.1	AdoHcyase	67..491	CDD:283003	313/424 (74%)
Ahcyl1	XP_008759627.2	AdoHcyase	106..529	CDD:214963	312/422 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341643
Domainoid	1	1.000	282	1.000	Domainoid score	I1576
eggNOG	1	0.900	-	-		E1_COG0499
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D207688at33208
OrthoFinder	1	1.000	-	-		FOG0003070
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104147
Panther	1	1.100	-	-	O	PTHR23420
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.750