Protein Alignment AhcyL2 and AHCYL1

DIOPT Version :10

• Sequence 1: NP_996221.1
• Gene: AhcyL2 / 42043
• FlyBaseID: FBgn0015011
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: NP_006612.2
• Gene: AHCYL1 / 10768
• HGNCID: 344
• Length: 530
• Species: Homo sapiens
• Alignment Length: 500
• Identity: 342/500 - (68%)
• Similarity: 408/500 - (81%)
• Gaps: 13/500 - (2%)

  Fly     1 MAKMP--ETTFAD-----LSLADKTAVKKSSIEARRFSDVSTCSFSSTC-FTGSSDEEDVSPKDN 57
            :.|.|  :..|||     .....||..:..|   |..|..||.|:||.. :|.|||:| |||::.
Human    34 VTKAPKKQIQFADDMQEFTKFPTKTGRRSLS---RSISQSSTDSYSSAASYTDSSDDE-VSPREK 94

  Fly    58 HQRNSAGGTDFCVKSISKSAFGRREIEIAESEMPGIMTLRKRAKDEKPLKGANIVGCTHVNAQSA 122
            .|.||.|.::||||:|.::.||||||||||.:|..:::|||||:.||||.||.||||||:.||:|
Human    95 QQTNSKGSSNFCVKNIKQAEFGRREIEIAEQDMSALISLRKRAQGEKPLAGAKIVGCTHITAQTA 159

  Fly   123 VLIETLVQLGATVRWAACNIYSTQNAVAAALAEAGIPIFAWRGETEEEFWWCLDRAIYSDGWQPN 187
            ||||||..|||..||:|||||||||.|||||||||:.:|||:||:|::||||:||.:..||||.|
Human   160 VLIETLCALGAQCRWSACNIYSTQNEVAAALAEAGVAVFAWKGESEDDFWWCIDRCVNMDGWQAN 224

  Fly   188 LILDDGGDATHLMLKKYPDYFKAIRGIVEESVTGVHRLYMLSKGGKLTVPAINVNDSVTKNKFDT 252
            :|||||||.||.:.||||:.||.||||||||||||||||.|||.|||.|||:||||||||.|||.
Human   225 MILDDGGDLTHWVYKKYPNVFKKIRGIVEESVTGVHRLYQLSKAGKLCVPAMNVNDSVTKQKFDN 289

  Fly   253 FYTCRDSILDSLKRTTDIMFGGKQVVICGYGDVGKGCAQSLKGQGCIVYVTEVDPICALQAAMDG 317
            .|.||:||||.||||||:||||||||:||||:|||||..:||..|.|||:||:||||||||.|||
Human   290 LYCCRESILDGLKRTTDVMFGGKQVVVCGYGEVGKGCCAALKALGAIVYITEIDPICALQACMDG 354

  Fly   318 FRVVRLNEVIRTVDVVVTATGNKNVITRDHMNRMKNGCILCNMGHSCSEIDVNGLHTPELTWERV 382
            ||||:||||||.||||:|.||||||:||:|::||||.||:||||||.:||||..|.|||||||||
Human   355 FRVVKLNEVIRQVDVVITCTGNKNVVTREHLDRMKNSCIVCNMGHSNTEIDVTSLRTPELTWERV 419

  Fly   383 RSQVDHIRWPDGRMIILLAEGRLVNLSCSTISSFVVSVASSTQALALIELFSAP-GRYKSDVYLL 446
            ||||||:.||||:.::|||||||:||||||:.:||:|:.::|||||||||::|| ||||.|||||
Human   420 RSQVDHVIWPDGKRVVLLAEGRLLNLSCSTVPTFVLSITATTQALALIELYNAPEGRYKQDVYLL 484

  Fly   447 PKKMDEYVASLHLATFDAHLTELTDEQSKFMGLNKAGPFKANYYR 491
            |||||||||||||.:||||||||||:|:|::||||.||||.||||
Human   485 PKKMDEYVASLHLPSFDAHLTELTDDQAKYLGLNKNGPFKPNYYR 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AhcyL2	NP_996221.1	AdoHcyase	69..491	CDD:214963	312/422 (74%)
AHCYL1	NP_006612.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	53..103		22/53 (42%)
		PEST. /evidence=ECO:0000269|PubMed:25237103	65..92		14/27 (52%)
		AdoHcyase	106..529	CDD:214963	312/422 (74%)
		Interaction with BCL2L10. /evidence=ECO:0000269|PubMed:27995898	138..201		46/62 (74%)
		NAD binding. /evidence=ECO:0000250	281..448		126/166 (76%)
		PDZ-binding. /evidence=ECO:0000250	520..530		7/9 (78%)