Protein Alignment MECP2 and mecp2

DIOPT Version :10

• Sequence 1: NP_001104262.1
• Gene: MECP2 / 4204
• HGNCID: 6990
• Length: 498
• Species: Homo sapiens
• Sequence 2: NP_997901.1
• Gene: mecp2 / 335250
• ZFINID: ZDB-GENE-030131-7190
• Length: 524
• Species: Danio rerio
• Alignment Length: 562
• Identity: 281/562 - (50%)
• Similarity: 334/562 - (59%)
• Gaps: 108/562 - (19%)

Human     6 AAAPSGGGGGGEEERL--EEKSEDQDLQGLKDKPLKFKKVKKDKKE-EKEGKHEPVQP-----SA 62
            |||.||      ||||  |:|:|||  :|.|||..|.||.||::.: ||......|.|     :.
Zfish     2 AAAESG------EERLRGEDKNEDQ--EGSKDKTQKHKKSKKERHDVEKLETTVSVPPPPSLFTQ 58

Human    63 HHSAEPAEAGKAETSEGS-GSAPAVPEASASPKQRRSIIRDRGPMYDDPTLPEGWTRKLKQRKSG 126
            ....:.|||||:|..:.. |:|.:.||:|||.|||||:||||||||:||:||:||||||||||||
Zfish    59 RDVGQQAEAGKSEPIDPEVGAALSAPESSASAKQRRSVIRDRGPMYEDPSLPQGWTRKLKQRKSG 123

Human   127 RSAGKYDVYLINPQGKAFRSKVELIAYFEKVGDTSLDPNDFDFTVTGRGSPSRREQKPPKKPKSP 191
            |||||:|||||||:||||||||||:|||:|||||..|||||||||||||||||||::||||||..
Zfish   124 RSAGKFDVYLINPEGKAFRSKVELMAYFQKVGDTITDPNDFDFTVTGRGSPSRREKRPPKKPKMV 188

Human   192 KAPGTGRGRGRPKGSGTTRPKAATSEGVQVKRVLEKSPGKLLVKMPF---QTSPG---GKAEGGG 250
            |.  :|||||||||||..|   ..:|||.||||:|||||||||||||   :|.||   |:|....
Zfish   189 KP--SGRGRGRPKGSGKVR---QATEGVAVKRVIEKSPGKLLVKMPFVAPKTEPGAPLGQAPVAK 248

Human   251 ATTSTQVMVIKRPGRKRKAEADPQAIPKKRGRKPGSV------------VAAAA---AEAKKKAV 300
            |          |.|||||:|.||.:.||||||||.:|            .||||   |||||||:
Zfish   249 A----------RRGRKRKSEQDPPSTPKKRGRKPATVSQSTVGTGSAAAYAAAAILTAEAKKKAL 303

Human   301 KESSIRSVQETVLPIKKRKTRETV---------SIEVKEVVKPLLVSTL---GEKSGKGLKTCKS 353
            ||||.:.|||..|||||||||||:         :.|..|  |.|..||:   ||::..|.|..|.
Zfish   304 KESSAKPVQERALPIKKRKTRETLEELEASTTSATETFE--KRLTASTVTPTGEEAETGQKPHKH 366

Human   354 PGRKSKESSPKGRSSSASS----PPK------------KEHHHHHHHSESPKAPVPLLPPLPPPP 402
            |.||.||:.| |.|||.::    .||            |.|||||||....:......|....|.
Zfish   367 PSRKHKEADP-GSSSSGTTASGVAPKSHKKRDQRGQHFKHHHHHHHHHHQHQHLQASTPSTYTPQ 430

Human   403 PEPESSEDPTS---PPEPQDLSSS-------VCKEEKMPRGGSLESDGCPKEPAKTQPAVATAAT 457
            ....|....|.   ..||||||:|       .|:||  .|.||..|    ::........:...|
Zfish   431 AHQLSLGHSTHGGLENEPQDLSTSRPKAEHVACREE--ARTGSSSS----RDSQNASKMASMTVT 489

Human   458 AAEKYKHRGEGERKDIV-SSSMPRPNREEPVDSRTPVTERVS 498
            ...|       |.:||| .|::|||:|||.|:|||||:|.||
Zfish   490 GESK-------ELRDIVPPSAVPRPSREETVESRTPVSEPVS 524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MECP2	NP_001104262.1	MBD	104..181	CDD:128673	67/76 (88%)
mecp2	NP_997901.1	MBD	101..175	CDD:128673	64/73 (88%)