Protein Alignment MECP2 and Mecp2

DIOPT Version :10

• Sequence 1: NP_001104262.1
• Gene: MECP2 / 4204
• HGNCID: 6990
• Length: 498
• Species: Homo sapiens
• Sequence 2: NP_001418483.1
• Gene: Mecp2 / 29386
• RGDID: 3075
• Length: 520
• Species: Rattus norvegicus
• Alignment Length: 505
• Identity: 476/505 - (94%)
• Similarity: 483/505 - (95%)
• Gaps: 11/505 - (2%)

Human     2 AAAAAAAPSGGGGGGEEERLEEKSEDQDLQGLKDKPLKFKKVKKDKKEEKEGKHEPVQPSAHHSA 66
            ||||||||| |||||||||||||||||||||||:||||||||||||||:|||||||:||||||||
  Rat    19 AAAAAAAPS-GGGGGEEERLEEKSEDQDLQGLKEKPLKFKKVKKDKKEDKEGKHEPLQPSAHHSA 82

Human    67 EPAEAGKAETSEGSGSAPAVPEASASPKQRRSIIRDRGPMYDDPTLPEGWTRKLKQRKSGRSAGK 131
            ||||||||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat    83 EPAEAGKAETSESSGSAPAVPEASASPKQRRSIIRDRGPMYDDPTLPEGWTRKLKQRKSGRSAGK 147

Human   132 YDVYLINPQGKAFRSKVELIAYFEKVGDTSLDPNDFDFTVTGRGSPSRREQKPPKKPKSPKAPGT 196
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   148 YDVYLINPQGKAFRSKVELIAYFEKVGDTSLDPNDFDFTVTGRGSPSRREQKPPKKPKSPKAPGT 212

Human   197 GRGRGRPKGSGTTRPKAATSEGVQVKRVLEKSPGKLLVKMPFQTSPGGKAEGGGATTSTQVMVIK 261
            ||||||||||||.|||||.||||||||||||||||||||||||.|||||.||||||||.||||||
  Rat   213 GRGRGRPKGSGTGRPKAAASEGVQVKRVLEKSPGKLLVKMPFQASPGGKGEGGGATTSAQVMVIK 277

Human   262 RPGRKRKAEADPQAIPKKRGRKPGSVVAAAAAEAKKKAVKESSIRSVQETVLPIKKRKTRETVSI 326
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   278 RPGRKRKAEADPQAIPKKRGRKPGSVVAAAAAEAKKKAVKESSIRSVQETVLPIKKRKTRETVSI 342

Human   327 EVKEVVKPLLVSTLGEKSGKGLKTCKSPGRKSKESSPKGRSSSASSPPKKEHHHHHHHSESPKAP 391
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||||
  Rat   343 EVKEVVKPLLVSTLGEKSGKGLKTCKSPGRKSKESSPKGRSSSASSPPKKEHHHHHHHAESPKAP 407

Human   392 VPLLPPLPPPPPEPESSEDPTSPPEPQDLSSSVCKEEKMPRGGSLESDGCPKEPAKTQPAVATAA 456
            :||||  |||||||:|||||.|||||||||||:||||||||.|||||||||||||||||.||.||
  Rat   408 MPLLP--PPPPPEPQSSEDPISPPEPQDLSSSICKEEKMPRAGSLESDGCPKEPAKTQPMVAAAA 470

Human   457 --------TAAEKYKHRGEGERKDIVSSSMPRPNREEPVDSRTPVTERVS 498
                    |.||||||||||||||||||||||||||||||||||||||||
  Rat   471 TTTTTTTTTVAEKYKHRGEGERKDIVSSSMPRPNREEPVDSRTPVTERVS 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MECP2	NP_001104262.1	MBD	104..181	CDD:128673	76/76 (100%)
Mecp2	NP_001418483.1	MBD	120..197	CDD:128673	76/76 (100%)