Protein Alignment MECP2 and Mecp2

DIOPT Version :10

• Sequence 1: NP_001104262.1
• Gene: MECP2 / 4204
• HGNCID: 6990
• Length: 498
• Species: Homo sapiens
• Sequence 2: NP_001075448.1
• Gene: Mecp2 / 17257
• MGIID: 99918
• Length: 501
• Species: Mus musculus
• Alignment Length: 496
• Identity: 473/496 - (95%)
• Similarity: 479/496 - (96%)
• Gaps: 2/496 - (0%)

Human     3 AAAAAAPSGGGGGGEEERLEEKSEDQDLQGLKDKPLKFKKVKKDKKEEKEGKHEPVQPSAHHSAE 67
            |||||||||||||||||||||||||||||||:||||||||.||||||:|||||||:|||||||||
Mouse     8 AAAAAAPSGGGGGGEEERLEEKSEDQDLQGLRDKPLKFKKAKKDKKEDKEGKHEPLQPSAHHSAE 72

Human    68 PAEAGKAETSEGSGSAPAVPEASASPKQRRSIIRDRGPMYDDPTLPEGWTRKLKQRKSGRSAGKY 132
            |||||||||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse    73 PAEAGKAETSESSGSAPAVPEASASPKQRRSIIRDRGPMYDDPTLPEGWTRKLKQRKSGRSAGKY 137

Human   133 DVYLINPQGKAFRSKVELIAYFEKVGDTSLDPNDFDFTVTGRGSPSRREQKPPKKPKSPKAPGTG 197
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   138 DVYLINPQGKAFRSKVELIAYFEKVGDTSLDPNDFDFTVTGRGSPSRREQKPPKKPKSPKAPGTG 202

Human   198 RGRGRPKGSGTTRPKAATSEGVQVKRVLEKSPGKLLVKMPFQTSPGGKAEGGGATTSTQVMVIKR 262
            |||||||||||.|||||.|||||||||||||||||:||||||.|||||.||||||||.|||||||
Mouse   203 RGRGRPKGSGTGRPKAAASEGVQVKRVLEKSPGKLVVKMPFQASPGGKGEGGGATTSAQVMVIKR 267

Human   263 PGRKRKAEADPQAIPKKRGRKPGSVVAAAAAEAKKKAVKESSIRSVQETVLPIKKRKTRETVSIE 327
            ||||||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||||
Mouse   268 PGRKRKAEADPQAIPKKRGRKPGSVVAAAAAEAKKKAVKESSIRSVHETVLPIKKRKTRETVSIE 332

Human   328 VKEVVKPLLVSTLGEKSGKGLKTCKSPGRKSKESSPKGRSSSASSPPKKEHHHHHHHSESPKAPV 392
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|||:
Mouse   333 VKEVVKPLLVSTLGEKSGKGLKTCKSPGRKSKESSPKGRSSSASSPPKKEHHHHHHHSESTKAPM 397

Human   393 PLLPPLPPPPPEPESSEDPTSPPEPQDLSSSVCKEEKMPRGGSLESDGCPKEPAKTQPAVATAAT 457
            ||||  .||||||||||||.|||||||||||:||||||||||||||||||||||||||.|||..|
Mouse   398 PLLP--SPPPPEPESSEDPISPPEPQDLSSSICKEEKMPRGGSLESDGCPKEPAKTQPMVATTTT 460

Human   458 AAEKYKHRGEGERKDIVSSSMPRPNREEPVDSRTPVTERVS 498
            .||||||||||||||||||||||||||||||||||||||||
Mouse   461 VAEKYKHRGEGERKDIVSSSMPRPNREEPVDSRTPVTERVS 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MECP2	NP_001104262.1	MBD	104..181	CDD:128673	76/76 (100%)
Mecp2	NP_001075448.1	MBD	109..186	CDD:128673	76/76 (100%)