Protein Alignment MECP2 and mecp2

DIOPT Version :10

• Sequence 1: NP_001104262.1
• Gene: MECP2 / 4204
• HGNCID: 6990
• Length: 498
• Species: Homo sapiens
• Sequence 2: NP_001135563.1
• Gene: mecp2 / 100216110
• XenbaseID: XB-GENE-494740
• Length: 466
• Species: Xenopus tropicalis
• Alignment Length: 504
• Identity: 339/504 - (67%)
• Similarity: 383/504 - (75%)
• Gaps: 50/504 - (9%)

Human     6 AAAPSGGGGGGEEERLEEKSEDQDLQGLKDKPLKFKKVKKDKKEEKEGKHEPVQPSAHHSAEPAE 70
            ||||||      |||||||||||||||.||||.|.:|||:|||:|:| |.|...||.|.|.|||:
 Frog     2 AAAPSG------EERLEEKSEDQDLQGQKDKPPKLRKVKRDKKDEEE-KQETFHPSEHQSGEPAD 59

Human    71 AGKAETSEGSGSAPAVPEASASPKQRRSIIRDRGPMYDDPTLPEGWTRKLKQRKSGRSAGKYDVY 135
            .|||:.||.:..:.||||||||||||||:||||||||:|||||||||||||||||||||||:|||
 Frog    60 EGKADISESAEESLAVPEASASPKQRRSVIRDRGPMYEDPTLPEGWTRKLKQRKSGRSAGKFDVY 124

Human   136 LINPQGKAFRSKVELIAYFEKVGDTSLDPNDFDFTVTGRGSPSRREQKPPKKPKSPKAPGTGRGR 200
            ||||.||||||||||||||:||||||||||||||||||||||||||||.|||.|:||:.||||||
 Frog   125 LINPNGKAFRSKVELIAYFQKVGDTSLDPNDFDFTVTGRGSPSRREQKQPKKSKAPKSSGTGRGR 189

Human   201 GRPKGSGTTRPKAATSEGVQVKRVLEKSPGKLLVKMPFQTSPGGKAEGGGATTSTQVMVIKRPGR 265
            ||||||...: ....|||||||||:|||||||||||||    .|..|...||||.||:|||||||
 Frog   190 GRPKGSVKVK-SPVKSEGVQVKRVIEKSPGKLLVKMPF----SGSKEESDATTSEQVLVIKRPGR 249

Human   266 KRKAEADPQAIPKKRGRKPGSV-VAAAAAE-AKKKAVKESSIRSVQETVLPIKKRKTRETVSIEV 328
            |||::.||.|.||||||||||| :|||||| |||||:|||||:.:.||||||||||||||:|::|
 Frog   250 KRKSDTDPSAAPKKRGRKPGSVSLAAAAAEAAKKKAIKESSIKPLLETVLPIKKRKTRETISVDV 314

Human   329 KEVVKPLLVSTLGEKSGKGLKTCKSPGRKSKESSPKGRSSSASSPPKKE---------HHHHHHH 384
            |:.|||.|::.:.|||.||.|..|||..:|.|.|||.::..    ||||         |||||||
 Frog   315 KDTVKPELLTPVIEKSIKGQKPAKSPESRSTEGSPKIKTGL----PKKELQQHHHHHHHHHHHHH 375

Human   385 SESPKAPVPLLPPLPPPPPEPESSEDPTSPPEPQDLSSSVCKEEKMPRGGSLESDGCPKEPAKTQ 449
            |||..:..         .||||:|:|....|||||||..:.||||:|     |||||.:||||||
 Frog   376 SESKASAT---------SPEPETSKDSIGAPEPQDLSVKIYKEEKLP-----ESDGCAQEPAKTQ 426

Human   450 PAVATAATAAEKYKHRGEGERKDIVSSSMPRPNREEPVDSRTPVTERVS 498
            |        |:|.::|.|||||||| ||:|||.||||||:||.||||||
 Frog   427 P--------ADKCRNRAEGERKDIV-SSVPRPTREEPVDTRTTVTERVS 466

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MECP2	NP_001104262.1	MBD	104..181	CDD:128673	72/76 (95%)
mecp2	NP_001135563.1	MBD	93..170	CDD:128673	72/76 (95%)