DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment abd-A and LHX4

DIOPT Version :9

Sequence 1:	NP_732176.1	Gene:	abd-A / 42037	FlyBaseID:	FBgn0000014	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_203129.1	Gene:	LHX4 / 89884	HGNCID:	21734	Length:	390	Species:	Homo sapiens

Alignment Length:	262	Identity:	56/262 - (21%)
Similarity:	91/262 - (34%)	Gaps:	77/262 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   384 RVVC-GDF-----NGPNGCPRRRGRQTYTRFQTLELEKEFHFNHYLTRRRRIEIAHALCLTERQI 442
            |:|| .|:     |..:....:|.|.|.|..|...|:..:..:....|..|.:::....|..|.:
Human   137 RLVCKEDYETAKQNDDSEAGAKRPRTTITAKQLETLKNAYKNSPKPARHVREQLSSETGLDMRVV 201

  Fly   443 KIWFQNRRMKLKKELRAVKEINEQARRDREEQEKMKAQETMKSAQQNKQ-------VQQQQQQQQ 500
            ::||||||.|.|:       :.:.|.|.|..|.....:.:..|::|.|:       |...:...:
Human   202 QVWFQNRRAKEKR-------LKKDAGRHRWGQFYKSVKRSRGSSKQEKESSAEDCGVSDSELSFR 259

  Fly   501 QQQQQQQQQH---------------------------QQQQ-----------QQPQDHHSIIAHN 527
            :.|...:..|                           |..|           |.|....|:.:|.
Human   260 EDQILSELGHTNRIYGNVGDVTGGQLMNGSFSMDGTGQSYQDLRDGSPYGIPQSPSSISSLPSHA 324

  Fly   528 P--GHLHHSVVGQNDLKLGLGMGVGVGVGGIGPGIGGG------LGGNLGMM-------SALDKS 577
            |  ..|.::|    |..||:....|.||......:.||      .|.::|..       |.||:.
Human   325 PLLNGLDYTV----DSNLGIIAHAGQGVSQTLRAMAGGPTSDISTGSSVGYPDFPTSPGSWLDEM 385

  Fly   578 NH 579
            :|
Human   386 DH 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
abd-A	NP_732176.1	Homeobox	402..454	CDD:278475	16/51 (31%)
abd-A	NP_732176.1	Abdominal-A	456..478	CDD:289192	4/21 (19%)
LHX4	NP_203129.1	LIM1_Lhx4	30..81	CDD:188852
		LIM2_Lhx3_Lhx4	89..144	CDD:188762	3/6 (50%)
		Homeobox	160..213	CDD:306543	16/52 (31%)
		Interaction with DNA. /evidence=ECO:0000305\|PubMed:28473536	161..181		5/19 (26%)
		Interaction with 5-mCpG DNA. /evidence=ECO:0000305\|PubMed:28473536	199..211		7/11 (64%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	230..253		4/22 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	356..390		8/32 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910