DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment abd-A and IRX6

DIOPT Version :9

Sequence 1:	NP_732176.1	Gene:	abd-A / 42037	FlyBaseID:	FBgn0000014	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_077311.2	Gene:	IRX6 / 79190	HGNCID:	14675	Length:	446	Species:	Homo sapiens

Alignment Length:	353	Identity:	71/353 - (20%)
Similarity:	126/353 - (35%)	Gaps:	112/353 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   191 PSAGNSQAGDSS--CSPSPSASGSSSLHRSLNDNSPGSASASA----------SASAASSVAAA- 242
            |..|:...|.|.  .|.|.|.:...|..||::|.:.||..|.|          ..||...:.||
Human     4 PHFGHPYRGASQFLASASSSTTCCESTQRSVSDVASGSTPAPALCCAPYDSRLLGSARPELGAAL 68

  Fly   243 ----AAAAAAAASSSFAIPTSKMYPYVSNHPSSHGGLSGMAGFTGLEDKSCSRYTDTVMNSYQSM 303
                |..|||||:.|:    ....||....||.:|.|:..
Human    69 GIYGAPYAAAAAAQSY----PGYLPYSPEPPSLYGALNPQ------------------------- 104

  Fly   304 SVPASASAQFAQFYQHATAAASAVSAASAGAIGVDSLGNACTQPASGVMPGAGGAGGAGIADLPR 368
                         |:...||.|..|:.:                    .|||            .
Human   105 -------------YEFKEAAGSFTSSLA--------------------QPGA------------Y 124

  Fly   369 YPW-MTLTDWMGSPFERVVCGDFNGPNGCPRRRGRQTYTRFQTLELE---KEFHFNHYLTRRRRI 429
            ||: .||..:.   :||....:.:|..      .|:..||..|..|:   .|...|.|.|:..:|
Human   125 YPYERTLGQYQ---YERYGAVELSGAG------RRKNATRETTSTLKAWLNEHRKNPYPTKGEKI 180

  Fly   430 EIAHALCLTERQIKIWFQNRRMKLKKELRAV----KEINEQARRDREEQEKMKA----QETMKSA 486
            .:|....:|..|:..||.|.|.:||||.:..    .:..|:.:.:..|::.:..    .:.:.::
Human   181 MLAIITKMTLTQVSTWFANARRRLKKENKMTWAPKNKGGEERKAEGGEEDSLGCLTADTKEVTAS 245

  Fly   487 QQNKQVQQQQQQQQQQQQQQQQQHQQQQ 514
            |:.:.::....:..:::::::::.:.::
Human   246 QEARGLRLSDLEDLEEEEEEEEEAEDEE 273

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
abd-A	NP_732176.1	Homeobox	402..454	CDD:278475	17/54 (31%)
abd-A	NP_732176.1	Abdominal-A	456..478	CDD:289192	3/25 (12%)
IRX6	NP_077311.2	Homeobox_KN	164..203	CDD:283551	12/38 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	208..273		3/64 (5%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	362..394
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910