DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment abd-A and ISL2

DIOPT Version :9

Sequence 1:	NP_732176.1	Gene:	abd-A / 42037	FlyBaseID:	FBgn0000014	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_665804.1	Gene:	ISL2 / 64843	HGNCID:	18524	Length:	359	Species:	Homo sapiens

Alignment Length:	155	Identity:	37/155 - (23%)
Similarity:	60/155 - (38%)	Gaps:	35/155 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   379 GSPFERVVCGDFNGPNGCPRRRG-------------------RQT--YTRFQTLELEKEFHF--N 420
            |...||...|....|...|..||                   :||  .||.:|:..||:.|.  .
Human   144 GLLLERAAAGSPRSPGPLPGARGLHLPDAGSGRQPALRPHVHKQTEKTTRVRTVLNEKQLHTLRT 208

  Fly   421 HYLTRRR-----RIEIAHALCLTERQIKIWFQNRRMKLKKELRAVKEINEQARRDREEQEKMKAQ 480
            .|....|     :.::.....|:.|.|::||||:|.|.||:...:|::.:|...|:...:.:...
Human   209 CYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKKSILMKQLQQQQHSDKTSLQGLTGT 273

  Fly   481 ETM-------KSAQQNKQVQQQQQQ 498
            ..:       ::|.|...|:.|..|
Human   274 PLVAGSPIRHENAVQGSAVEVQTYQ 298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
abd-A	NP_732176.1	Homeobox	402..454	CDD:278475	19/60 (32%)
abd-A	NP_732176.1	Abdominal-A	456..478	CDD:289192	3/21 (14%)
ISL2	NP_665804.1	LIM1_Isl	27..81	CDD:188752
		LIM2_Isl2	89..143	CDD:188855
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..191		7/39 (18%)
		HOX	191..247	CDD:197696	17/55 (31%)
		LIM-binding domain (LID). /evidence=ECO:0000250	272..301		5/27 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	326..359
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910