DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment abd-A and UNCX

DIOPT Version :9

Sequence 1:	NP_732176.1	Gene:	abd-A / 42037	FlyBaseID:	FBgn0000014	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_001073930.1	Gene:	UNCX / 340260	HGNCID:	33194	Length:	531	Species:	Homo sapiens

Alignment Length:	334	Identity:	82/334 - (24%)
Similarity:	125/334 - (37%)	Gaps:	100/334 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   268 HPSSH--GGLSGMAGFTGLEDKSCSRYTDTVMNSYQSMSVPASASAQFAQFYQHATAAASAVSAA 330
            ||.:.  |.|.|:.||    ......:....:..:|..|..|:||..|:
Human     9 HPHAQFGGSLGGVVGF----PYPLGHHHVYELAGHQLQSAAAAASVPFS---------------- 53

  Fly   331 SAGAIGVDS-LGNACTQPASGV-----MPGAGGAGGAGIADLPRYPWMTLTDWMGSPFERVVCGD 389
                  :|. ||.:|...||.|     :|.|.|.||.                 |.||:....||
Human    54 ------IDGLLGGSCAAAASVVNPTPLLPAACGVGGD-----------------GQPFKLSDSGD 95

  Fly   390 FNGPN----GCPRRRGRQTYTRFQTLELEKEFHFNHYLTRRRRIEIAHALCLTERQIKIWFQNRR 450
               |:    ||.|||.|..:|.:|..||||.|:.:||.....|..:|..|.|.|.::::||||||
Human    96 ---PDKESPGCKRRRTRTNFTGWQLEELEKAFNESHYPDVFMREALALRLDLVESRVQVWFQNRR 157

  Fly   451 MKLKKELRAVKEINEQARRDRE---EQEKMKAQETMKSAQQNKQVQQQQQQQQQQQQQQQQQHQQ 512
            .|.:|:....|.....|.....   ..|.|..:|..:             ::.::.::::::|::
Human   158 AKWRKKENTKKGPGRPAHNSHPTTCSGEPMDPEEIAR-------------KELEKMEKKKRKHEK 209

  Fly   513 QQQQPQDHHSIIAHNPG--HLHHSVVGQNDLKLGLGMGVGVGVGGIGP-----------GIGGGL 564
            :..:.|..|   .|:||  .||.:....:|          .|.||:.|           |.|...
Human   210 KLLKSQGRH---LHSPGGLSLHSAPSSDSD----------SGGGGLSPEPPEPPPPAAKGPGAHA 261

  Fly   565 GGNLGMMSA 573
            .|..|...|
Human   262 SGAAGTAPA 270

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
abd-A	NP_732176.1	Homeobox	402..454	CDD:278475	22/51 (43%)
abd-A	NP_732176.1	Abdominal-A	456..478	CDD:289192	3/24 (13%)
UNCX	NP_001073930.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	87..107		8/22 (36%)
		Homeobox	108..161	CDD:306543	22/52 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	161..312		24/136 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	324..344
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	401..531
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910