DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment abd-A and HOXD3

DIOPT Version :9

Sequence 1:	NP_732176.1	Gene:	abd-A / 42037	FlyBaseID:	FBgn0000014	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_008829.3	Gene:	HOXD3 / 3232	HGNCID:	5137	Length:	432	Species:	Homo sapiens

Alignment Length:	253	Identity:	77/253 - (30%)
Similarity:	107/253 - (42%)	Gaps:	65/253 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   274 GLSGMAGFTGLEDKSCSRYTDTVMNS--YQSMSVPASASAQFAQFYQHATAAASAVSAASAGAIG 336
            ||.|..|:        |:.|||...|  :|....||:||:....:...|.:..|:....:....|
Human    27 GLFGGYGY--------SKTTDTYGYSTPHQPYPPPAAASSLDTDYPGSACSIQSSAPLRAPAHKG 83

  Fly   337 VDSLGNACTQPASGVMPGAGGA------------------------------GGAGIADLPR--- 368
            .: |..:|.:|.:|...|.||.                              ||...|..|:
Human    84 AE-LNGSCMRPGTGNSQGGGGGSQPPGLNSEQQPPQPPPPPPTLPPSSPTNPGGGVPAKKPKGGP 147

  Fly   369 -------------YPWMTLTDWMGSPFERVVCG------DFNGPNGCPRRRGRQTYTRFQTLELE 414
                         :|||  .:...:..::..|.      :...|.|...:|.|..||..|.:|||
Human   148 NASSSSATISKQIFPWM--KESRQNSKQKNSCATAGESCEDKSPPGPASKRVRTAYTSAQLVELE 210

  Fly   415 KEFHFNHYLTRRRRIEIAHALCLTERQIKIWFQNRRMKLKKELRAVKEINEQARRDRE 472
            ||||||.||.|.||:|:|:.|.||||||||||||||||.||:.:|...::..|.:..|
Human   211 KEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKKDQKAKGILHSPASQSPE 268

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
abd-A	NP_732176.1	Homeobox	402..454	CDD:278475	37/51 (73%)
abd-A	NP_732176.1	Abdominal-A	456..478	CDD:289192	3/17 (18%)
HOXD3	NP_008829.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	43..62		6/18 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	68..197		19/131 (15%)
		Antp-type hexapeptide	160..165		3/6 (50%)
		Homeobox	198..250	CDD:306543	37/51 (73%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	253..280		3/16 (19%)
		DUF4074	369..430	CDD:315871
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	400..432
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810