DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment abd-A and HOXA3

DIOPT Version :9

Sequence 1:	NP_732176.1	Gene:	abd-A / 42037	FlyBaseID:	FBgn0000014	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_001371264.1	Gene:	HOXA3 / 3200	HGNCID:	5104	Length:	443	Species:	Homo sapiens

Alignment Length:	282	Identity:	79/282 - (28%)
Similarity:	102/282 - (36%)	Gaps:	64/282 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   190 PPSAGNSQAGDSSCSPSPSAS---GSSSLHR-SLNDNSPGSASASASASAASSVAAAAAAAAAAA 250
            |..|.|..|.:::..|.|:::   .....|| :.:..||.||.....|...|.......:|..:.
Human    17 PYQAANGFAYNANQQPYPASAALGADGEYHRPACSLQSPSSAGGHPKAHELSEACLRTLSAPPSQ 81

  Fly   251 SSSFAIPTSKMYPYVSNHPSSHGGLSGMAGFTGLEDKSCSRYTDTVMNSYQSMSVPASASAQFAQ 315
            ..|...|..        ||.                                   |..|:....|
Human    82 PPSLGEPPL--------HPP-----------------------------------PPQAAPPAPQ 103

  Fly   316 FYQHATAAASAVSAASAGAIGVDSLGNACTQPASGVMPGAGGAGGAGIADLPR-----YPWM--- 372
            ..|.|....:...||...........||...|.      ...|..:.:.:.|.     :|||
Human   104 PPQPAPQPPAPTPAAPPPPSSASPPQNASNNPT------PANAAKSPLLNSPTVAKQIFPWMKES 162

  Fly   373 ---TLTDWMGSPFERVVCGDFNGPNGCPRRRGRQTYTRFQTLELEKEFHFNHYLTRRRRIEIAHA 434
               |......|.......||.:.|.....:|.|..||..|.:|||||||||.||.|.||:|:|:.
Human   163 RQNTKQKTSSSSSGESCAGDKSPPGQASSKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANL 227

  Fly   435 LCLTERQIKIWFQNRRMKLKKE 456
            |.||||||||||||||||.||:
Human   228 LNLTERQIKIWFQNRRMKYKKD 249

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
abd-A	NP_732176.1	Homeobox	402..454	CDD:278475	37/51 (73%)
abd-A	NP_732176.1	Abdominal-A	456..478	CDD:289192	0/1 (0%)
HOXA3	NP_001371264.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	75..147		16/120 (13%)
		Antp-type hexapeptide	155..160		2/4 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	159..196		7/36 (19%)
		Homeobox	195..248	CDD:395001	37/52 (71%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	247..338		2/3 (67%)
		DUF4074	378..441	CDD:404218
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	400..443
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810