DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment abd-A and ARX

DIOPT Version :9

Sequence 1:	NP_732176.1	Gene:	abd-A / 42037	FlyBaseID:	FBgn0000014	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_620689.1	Gene:	ARX / 170302	HGNCID:	18060	Length:	562	Species:	Homo sapiens

Alignment Length:	395	Identity:	100/395 - (25%)
Similarity:	147/395 - (37%)	Gaps:	120/395 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 SPVSSSSPFQQHHPQVQQQHLNHQQQQHLHHQQQQHHHQYSSLSAALQLQQQQHHISKLAAAAVA 177
            ||.|||:||:      .:.|| ..:.:.|:........|.::.:||             ||||.|
Human    67 SPKSSSAPFE------AELHL-PPKLRRLYGPGGGRLLQGAAAAAA-------------AAAAAA 111

  Fly   178 SHGHAHQQLLLTPPSAGNSQAGDSSCSPSPSASGSSSLHRSLNDNSPGSASASASASAASSVAAA 242
            :             :|..:.||....:|.|               .|.:|........|.:.|||
Human   112 A-------------AAATATAGPRGEAPPP---------------PPPTARPGERPDGAGAAAAA 148

  Fly   243 AAAAAAA-------ASSSFAIPTSKMY-----PYVS--------------NHPSSHGGLSG---- 277
            |||||||       .:...:|..||.|     |:|.              .||....|::|
Human   149 AAAAAAAWDTLKISQAPQVSISRSKSYRENGAPFVPPPPALDELGGPGGVTHPEERLGVAGGPGS 213

  Fly   278 ---MAGFTG--------LEDKSCSRYTDTVMNSYQSMSVPASASAQFAQFYQHATAAASAVSAAS 331
               ..|.||        |||:......:.::...:...:...|.|...:..:...||..||:||:
Human   214 APAAGGGTGTEDDEEELLEDEEDEDEEEELLEDDEEELLEDDARALLKEPRRCPVAATGAVAAAA 278

  Fly   332 AGAIGVDSLGNACTQPASGVMPGAGGAGG--AGIADLPRYPWMTLTDWMGSPFERVVC--GDFNG 392
            |.|:..:                    ||  :...:|..:|    .|..|...|..||  ...:.
Human   279 AAAVATE--------------------GGELSPKEELLLHP----EDAEGKDGEDSVCLSAGSDS 319

  Fly   393 PNGC---PRRRGRQTYTRFQTLELEKEFHFNHYLTRRRRIEIAHALCLTERQIKIWFQNRRMKLK 454
            ..|.   .:||.|.|:|.:|..|||:.|...||.....|.|:|..|.|||.::::||||||.|.:
Human   320 EEGLLKRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWR 384

  Fly   455 KELRA 459
            |..:|
Human   385 KREKA 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
abd-A	NP_732176.1	Homeobox	402..454	CDD:278475	24/51 (47%)
abd-A	NP_732176.1	Abdominal-A	456..478	CDD:289192	1/4 (25%)
ARX	NP_620689.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	50..81		7/19 (37%)
		GCG-encoded polyalanine repeat	102..111		6/21 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	118..255		33/151 (22%)
		Homeobox	332..385	CDD:395001	24/52 (46%)
		OAR	526..544	CDD:397759
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	530..543
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910