DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment abd-A and Zfhx3

DIOPT Version :9

Sequence 1:	NP_732176.1	Gene:	abd-A / 42037	FlyBaseID:	FBgn0000014	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_031522.2	Gene:	Zfhx3 / 11906	MGIID:	99948	Length:	3723	Species:	Mus musculus

Alignment Length:	889	Identity:	163/889 - (18%)
Similarity:	245/889 - (27%)	Gaps:	404/889 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 TTTPPN------------SSSAAVAAALAAAAASASASVSASSSSNNNSSNTIAGSNTSNTNNSS 78
            |::|.|            |.|:.:...:.:......|..:...:::.||:.|   .|:...:.||
Mouse  1598 TSSPDNKPFKCNTCNVAYSQSSTLEIHMRSVLHQTKARAAKLEAASGNSNGT---GNSGGVSLSS 1659

  Fly    79 SSPS---SSSNNN--SNLNLSGGSLSPS--HLSQ---------HLGQ-------SPHSP------ 114
            |:||   ||..||  :..|.|..:::||  .|||         .||.       ||..|
Mouse  1660 STPSPVGSSGANNTFTATNPSSAAMAPSVNALSQVPPESVVMPPLGNPISANIASPSEPKEANRK 1724

  Fly   115 -----VSSSSPFQQHHPQVQQQ-----HLNHQQQQHLHHQQQQH--------------HHQYSSL 155
                 ::|....||...|.|||     ....|.|.||..:.||.              .|...:.
Mouse  1725 KLADMIASRQQQQQQQQQQQQQAQTLAQAQAQVQAHLQQELQQQAALIQSQLFNPTLLPHFPMTT 1789

  Fly   156 SAALQLQQQQH----------------HIS-KLAAAAVASHG-----------------HAHQQL 186
            ...||||||||                .:| .:.:.|:...|                 .:|||:
Mouse  1790 ETLLQLQQQQHLLFPFYIPSAEFQLNPEVSLPVTSGALTLTGSGPGLLEDLKAQVQIPQQSHQQI 1854

  Fly   187 LLTPPSAGN---SQAGDSSCSPS-------------------------PSASGSSSLHRSLNDNS 223
            |........   ||:..:...||                         ..|.|::....||.|.|
Mouse  1855 LQQQQQQSQLSLSQSHSALLQPSQHPEKKNKVVIKEKDKESQREREGPEGAEGNTGPKESLPDAS 1919

  Fly   224 ---------PGSAS-ASASASAASSVAAAAAAAAAAASSSFAI----PTSKMYPYVSNHPSSHGG 274
                     ||..| .:......:|.|...|..|...:..|.:    ..:|......|..:..||
Mouse  1920 KAKEKKDLAPGGGSEGTMLPPRIASDARGNATKALLENFGFELVIQYNENKQKAQKKNGKAEQGG 1984

  Fly   275 LSGMAGFTGLEDKSCSRYTDT--VMNSYQ----SMSVPASASAQFA-QFYQH------------- 319
            .|    ...||..||.:....  ::.|:|    ....|.....:|| |:.:|
Mouse  1985 ES----LEKLECDSCGKLFSNILILKSHQEHVHQNYFPFKQLERFAKQYREHYDKLYPLRPQTPE 2045

  Fly   320 -------------ATAAASAVSAAS--AGAIGVDSLGNACTQPA---------------SGVM-- 352
                         .||.....||.:  |.|..:.|...|..||:               |.:|
Mouse  2046 PPPPPPPPPPPPLPTAPPQPASAPAIPASAPPITSPTIAPAQPSVPLTQLSMPMELPIFSPLMMQ 2110

  Fly   353 ------------PGAGGAG--GAGIADLPRY-------------PWMTLTDWM-----------G 379
                        |..|...  .|.:|.|.::             |...:||..           .
Mouse  2111 TMPLQTLPAQLPPQLGPVEPLPADLAQLYQHQLNPTLLQQQNKRPRTRITDDQLRVLRQYFDINN 2175

  Fly   380 SPFERVV--CGDFNG---------------------------------------------PNGCP 397
            ||.|..:  ..|.:|                                             |:..|
Mouse  2176 SPSEEQIKEMADKSGLPQKVIKHWFRNTLFKERQRNKDSPYNFSNPPITSLEELKIDSRPPSPEP 2240

  Fly   398 --------RRRGRQTYTRFQTLELEKEFHFNHYLTRRRRIEIAHALCLTERQIKIWFQNRRMKLK 454
                    :|..|..:|.:|...|:..|..|.|.......::::.|.|..|.|.:||||.|.|.:
Mouse  2241 QKQEYWGSKRSSRTRFTDYQLRVLQDFFDANAYPKDDEFEQLSNLLNLPTRVIVVWFQNARQKAR 2305

  Fly   455 K-----------ELRAV-------------------------------------KEINEQARRDR 471
            |           |.|.:                                     |:.:|:.:.|.
Mouse  2306 KNYENQGEGKDGERRELTNDRYIRTSNLNYQCKKCSLVFQRIFDLIKHQKKLCYKDEDEEGQDDS 2370

  Fly   472 EEQEKMKAQETM----------------------------------------------------- 483
            :.::.|.|.|.:
Mouse  2371 QNEDSMDAMEILTPTSSSCSTPMPSQAYSTPAPSAAAANTAPSAFLQLTAETDELATFNSKAEAS 2435

  Fly   484 ---------KSAQQNKQVQQQQQQQQQQQQQQQQQHQQQQQQPQ 518
                     .|||.| |.|::|.|.:.:.|||.:|.:|:...||
Mouse  2436 DEKPKQADPPSAQPN-QTQEKQGQPKPEMQQQLEQLEQKTNAPQ 2478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
abd-A	NP_732176.1	Homeobox	402..454	CDD:278475	17/51 (33%)
abd-A	NP_732176.1	Abdominal-A	456..478	CDD:289192	5/58 (9%)
Zfhx3	NP_031522.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..79
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	95..129
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	417..557
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	590..621
		C2H2 Zn finger	674..694	CDD:275368
		C2H2 Zn finger	729..746	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1125..1228
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1320..1361
		C2H2 Zn finger	1375..1395	CDD:275368
		C2H2 Zn finger	1413..1433	CDD:275371
		C2H2 Zn finger	1441..1462	CDD:275371
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1500..1539
		C2H2 Zn finger	1557..1581	CDD:275368
		C2H2 Zn finger	1608..1626	CDD:275368	2/17 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1639..1678		13/41 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1706..1738		4/31 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1866..1943		13/76 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2037..2089		9/51 (18%)
		HOX	2152..2208	CDD:197696	8/55 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2211..2249		2/37 (5%)
		Homeobox	2252..2306	CDD:365835	17/53 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2383..2405		0/21 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2429..2529		15/51 (29%)
		COG5576	2603..2747	CDD:227863
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:Q15911	2624..2626
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2628..2656
		Homeobox	2654..2707	CDD:365835
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2780..2805
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2850..2877
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2920..2955
		Homeobox	2958..3011	CDD:365835
		Herpes_BLLF1	<3112..>3191	CDD:282904
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3145..3274
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3412..3473
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3585..3723
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910