DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment abd-A and Hoxa1

DIOPT Version :9

Sequence 1:	NP_732176.1	Gene:	abd-A / 42037	FlyBaseID:	FBgn0000014	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_037207.2	Gene:	Hoxa1 / 103690132	RGDID:	11414885	Length:	334	Species:	Rattus norvegicus

Alignment Length:	343	Identity:	91/343 - (26%)
Similarity:	123/343 - (35%)	Gaps:	101/343 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 LQLQQQQHHISKLAAAAVASHGHAHQQLLLTPPSAGN--SQAGDSSCSPSPSASGSSSLHRSLND 221
            :|:....||           |.|.|.....|..::||  .....|||.||..|...|:.:
  Rat    59 VQITSPHHH-----------HHHHHHPQPATYQTSGNLGVSYSHSSCGPSYGAQNFSAPY----- 107

  Fly   222 NSPGSASASASASAASSVAAAAAAAAAAASSSFAIPTSKMYPYVSNHPSSHGGLSGMAGFT---- 282
               |....:..|..:......|.|..:...||         |.|.:|....|...|..|..
  Rat   108 ---GPYGLNQEADVSGGYPPCAPAVYSGNLSS---------PMVQHHHHHQGYAGGTVGSPQYIH 160

  Fly   283 ---GLEDKSCSRYTDTVMNSYQSMSVPASASAQFAQFYQHATAAASAVSAASAGAIGVDSLGNAC 344
               |.|.:|.:      :.:|.:...|..||.|                             .||
  Rat   161 HSYGQEHQSLA------LATYNNSLSPLHASHQ-----------------------------EAC 190

  Fly   345 TQPASGVMPGAGGAGGAGIADLPRYPWMTLTDWM---GSPFERVVCGDF---NGPNGCPRRRGRQ 403
            ..|||....                |..|. |||   .:|.:....|::   ..||..     |.
  Rat   191 RSPASETSS----------------PAQTF-DWMKVKRNPPKTGKVGEYGYVGQPNAV-----RT 233

  Fly   404 TYTRFQTLELEKEFHFNHYLTRRRRIEIAHALCLTERQIKIWFQNRRMKLKK-ELRAVKEINEQA 467
            .:|..|..|||||||||.||||.||:|||.:|.|.|.|:||||||||||.|| |...:..|:...
  Rat   234 NFTTKQLTELEKEFHFNKYLTRARRVEIAASLQLNETQVKIWFQNRRMKQKKREKEGLLPISPAT 298

  Fly   468 RRDREEQEKMKAQETMKS 485
            ....:|:.:..::::..|
  Rat   299 PPGSDEKTEESSEKSSSS 316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
abd-A	NP_732176.1	Homeobox	402..454	CDD:278475	35/51 (69%)
abd-A	NP_732176.1	Abdominal-A	456..478	CDD:289192	3/21 (14%)
Hoxa1	NP_037207.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	61..82		6/31 (19%)
		Interaction with OGT. /evidence=ECO:0000250\|UniProtKB:P09022	74..202		36/195 (18%)
		COG5576	175..>285	CDD:227863	54/160 (34%)
		Antp-type hexapeptide	203..208		3/5 (60%)
		Homeobox	232..284	CDD:278475	35/51 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	280..334		9/37 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910