DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment abd-A and hoxd3

DIOPT Version :9

Sequence 1:	NP_732176.1	Gene:	abd-A / 42037	FlyBaseID:	FBgn0000014	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	XP_002935734.1	Gene:	hoxd3 / 100038058	XenbaseID:	XB-GENE-478462	Length:	415	Species:	Xenopus tropicalis

Alignment Length:	405	Identity:	107/405 - (26%)
Similarity:	150/405 - (37%)	Gaps:	121/405 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   194 GNSQAGDSSCSPSPSASGSSSLHRSLNDNSPGSASASASASAASSVAAAAAAAAAAASSSFAIPT 258
            |.:.|...|.|..||           ....|.|:..|...|.|.|:..||..|
Frog    31 GYTYAKPESYSYGPS-----------QQQYPQSSLDSDYPSTACSIQPAAIRA------------ 72

  Fly   259 SKMYPYVSNHPSSHGGLSGMAGFTGLEDKSCSRYTDTVMNSYQSMSVPASASAQFAQFYQHATAA 323
                   .||.::  .:||          ||.|.|.: .||.|:.|:    |.|     ||...:
Frog    73 -------PNHKAN--DISG----------SCMRTTSS-QNSNQAPSI----SNQ-----QHQAPS 108

  Fly   324 ASAVSAASAGAIGVDSLGNACTQPASGVMPGAGGAGGAGIADLPR--YPWM-----------TLT 375
            ....|         .|.||:..|..|    .:..:.|:..|.|.:  :|||           |.:
Frog   109 LPPSS---------PSHGNSSAQKKS----KSSNSSGSSQATLSKQIFPWMKESRQNAKQKNTSS 160

  Fly   376 DWMGSPFERVVCGDFNGPNGCPRRRGRQTYTRFQTLELEKEFHFNHYLTRRRRIEIAHALCLTER 440
            .....|.|.  |.: ..|.|...:|.|..||..|.:|||||||||.||.|.||:|:|:.|.||||
Frog   161 SSSTPPGEN--CEE-KSPTGPSSKRVRTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTER 222

  Fly   441 QIKIWFQNRRMKLKKELRAVKEINEQARRDREEQEKMKAQETMKSAQQNKQVQQQQQQQQQQQQQ 505
            ||||||||||||.||:.:|...::..|.:..:....:.....:..:.|...|.............
Frog   223 QIKIWFQNRRMKYKKDQKAKGIMHSPAGQSPDRSPTLSGSNHVGYSSQLPTVNSLSYDAPSPTSF 287

  Fly   506 QQQQHQQQQQQPQDHHSIIAHN-------------PG--HLHHSVVGQNDLKLGLGMGVGVGVGG 555
            .:.|        |:.:.:.|:.             ||  :.||::.|.:              |.
Frog   288 AKSQ--------QNMYGLAAYTAPLSSCLPQQKRYPGAEYEHHTMQGNS--------------GF 330

  Fly   556 IGPGIGGG---LGGN 567
            ..|.:.|.   :|||
Frog   331 ANPNLQGSPVYVGGN 345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
abd-A	NP_732176.1	Homeobox	402..454	CDD:278475	37/51 (73%)
abd-A	NP_732176.1	Abdominal-A	456..478	CDD:289192	2/21 (10%)
hoxd3	XP_002935734.1	Homeobox	184..237	CDD:365835	37/52 (71%)
hoxd3	XP_002935734.1	DUF4074	352..413	CDD:372548
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910