DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Glut3 and HXT13

DIOPT Version :9

Sequence 1:	NP_536732.1	Gene:	Glut3 / 42036	FlyBaseID:	FBgn0015230	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_010845.1	Gene:	HXT13 / 856640	SGDID:	S000000795	Length:	564	Species:	Saccharomyces cerevisiae

Alignment Length:	537	Identity:	116/537 - (21%)
Similarity:	209/537 - (38%)	Gaps:	87/537 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 GGIQDAE-PVEPPQSSRKSGTWFAKRPSEMPERHVERAPVRQKINNVGLYKATLYSNIGSFF--- 64
            |.::||: .|.||.....|..:   ..:|:........|.|..|..:.:|......:.|.|.
Yeast    12 GDVRDADIHVAPPVEKEWSDGF---DDNEVINGDNVEPPKRGLIGYLVIYLLCYPISFGGFLPGW 73

  Fly    65 -FGIAVGWSGTAERSVMEQHSYSFQPTELQWSGV-----CILLTLGAALWCLPMGLMVRLLGCRR 123
             .||..|:. ..:...|...||.....|...|.|     ..:.::|.|:..|....:...||.|.
Yeast    74 DSGITAGFI-NMDNFKMNFGSYKHSTGEYYLSNVRMGLLVAMFSIGCAIGGLIFARLADTLGRRL 137

  Fly   124 TILIQLLPNFLG----------WFLTVFARSVPMLYAGRFFLGMCGGAHCVVVPIYNAEISTTKK 178
            .|:|.:|...:|          |:         ..:.|:...|:..|...|:.|:..:||:.|..
Yeast   138 AIVIVVLVYMVGAIIQISSNHKWY---------QYFVGKIIYGLGAGGCSVLCPMLLSEIAPTDL 193

  Fly   179 RGAMGVVFEGACICGVIYSFAMSLFLELRIINF----VNLGLLALGPL-----QILMPESPAYYV 234
            ||.:..:::.....|:...:. |::...:..|.    |.|||..|..|     .:|:||||.|.:
Yeast   194 RGGLVSLYQLNMTFGIFLGYC-SVYGTRKYDNTAQWRVPLGLCFLWALIIIIGMLLVPESPRYLI 257

  Fly   235 DHGNIPRAEDSLRFLRGQKYDTRREIDFLTRDPTE------SEREVRQG---PLLGFKYKKVRRS 290
            :......|..|:..:.    ....|..::.:...|      ::||:.:.   .|...|.|.::|.
Yeast   258 ECERHEEARASIAKIN----KVSPEDPWVLKQADEINAGVLAQRELGEASWKELFSVKTKVLQRL 318

  Fly   291 LARSLAIALLQKLCGALIFIFYGLNMLDCLRIRREFGLILCLGLILGF--LACFFLVDRLGRRPL 353
            :...|....|| |.|...|.|||..:...:.:...|...:.||.:..|  :....:||::|||..
Yeast   319 ITGILVQTFLQ-LTGENYFFFYGTTIFKSVGLTDGFETSIVLGTVNFFSTIIAVMVVDKIGRRKC 382

  Fly   354 LIFSSAGIVFVSIYLGLHFKVWMTMGLTVM---------------SWIALFCIAIFVGCYTAGVG 403
            |:|.:||::...:       ::.::|:..:               :.|...|..||  |:.....
Yeast   383 LLFGAAGMMACMV-------IFASIGVKCLYPHGQDGPSSKGAGNAMIVFTCFYIF--CFATTWA 438

  Fly   404 SLTWVLNAELLVRPMRPLGCSIVCAFNWLTAFFVICWFGSHGVKCQPYLFLLFAIIASLILLFSL 468
            .:.:::.||.....::....||..|.|||..|.:  .|.:..:....:.:..:..:..|:.:|..
Yeast   439 PVAYIVVAESFPSKVKSRAMSISTACNWLWQFLI--GFFTPFITGSIHFYYGYVFVGCLVAMFLY 501

  Fly   469 I--YIPETKKLSSAKIQ 483
            :  ::|||..||..:||
Yeast   502 VFFFLPETIGLSLEEIQ 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glut3	NP_536732.1	Sugar_tr	60..484	CDD:278511	104/480 (22%)
Glut3	NP_536732.1	MFS	63..>226	CDD:119392	40/190 (21%)
HXT13	NP_010845.1	Sugar_tr	60..521	CDD:395036	104/486 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342372
Domainoid	1	1.000	165	1.000	Domainoid score	I819
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	165	1.000	Inparanoid score	I1037
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
TreeFam	0	0.000	Not matched by this tool.
	6	5.790