DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Glut3 and HXT4

DIOPT Version :9

Sequence 1:	NP_536732.1	Gene:	Glut3 / 42036	FlyBaseID:	FBgn0015230	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_011960.2	Gene:	HXT4 / 856492	SGDID:	S000001134	Length:	576	Species:	Saccharomyces cerevisiae

Alignment Length:	558	Identity:	112/558 - (20%)
Similarity:	214/558 - (38%)	Gaps:	129/558 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 AEPVEPPQSSRKSGTWFAKRPSEMPER---------HVERAPVRQKINNVGLYK--ATLYSNIG- 61
            |:.:.|.:|...|.   ...||...||         |.|      ..|.|.:.|  |:.|..:.
Yeast    18 ADALSPVESDSNSA---LSTPSNKAERDDMKDFDENHEE------SNNYVEIPKKPASAYVTVSI 73

  Fly    62 ----SFFFGIAVGW-SGT----------AERSVMEQHSYSFQPTELQWSGVCILLTLGAALWCLP 111
                ..|.|...|| :||          ..|..|:.|..::..::::...:..:..:|.|:..:.
Yeast    74 CCLMVAFGGFVFGWDTGTISGFVAQTDFIRRFGMKHHDGTYYLSKVRTGLIVSIFNIGCAIGGII 138

  Fly   112 MGLMVRLLGCRRTILIQLLPNFLG----------WFLTVFARSVPMLYAGRFFLGMCGGAHCVVV 166
            :..:..:.|.:..:::.::...:|          |:         ..:.||...|:..|...|:.
Yeast   139 LAKLGDMYGRKMGLIVVVVIYIIGIIIQIASINKWY---------QYFIGRIISGLGVGGIAVLS 194

  Fly   167 PIYNAEISTTKKRGAMGVVFEGACICGVIYSFAMSL-------FLELRIINFVNLG----LLALG 220
            |:..:|:|....||.:...::.....|:...:..:.       .::.|:.  :.||    |..:|
Yeast   195 PMLISEVSPKHIRGTLVSCYQLMITLGIFLGYCTNYGTKTYTNSVQWRVP--LGLGFAWALFMIG 257

  Fly   221 PLQILMPESPAYYVDHGNIPRAEDSLRFLRGQKYD---TRREIDFLTRDPTESER---EVRQGPL 279
            .: ..:||||.|.|:.|.|..|:.|:........|   ...|:: :.:...|:|:   ....|.:
Yeast   258 GM-TFVPESPRYLVEVGKIEEAKRSIALSNKVSADDPAVMAEVE-VVQATVEAEKLAGNASWGEI 320

  Fly   280 LGFKYKKVRRSLARSLAIALLQKLCGALIFIFYGLNMLDCLRIRREFGLILCLGLILGFLACF-- 342
            ...|.|..:| |.....|..||:|.|...|.:||..:...:.:...|...:.|| |:.|.:.|
Yeast   321 FSTKTKVFQR-LIMGAMIQSLQQLTGDNYFFYYGTTVFTAVGLEDSFETSIVLG-IVNFASTFVG 383

  Fly   343 -FLVDRLGRRPLLIFSSAGIVFVSIYLGLHFKVWMTMGLTVMSW----------------IALFC 390
             |||:|.|||..|::.:|.:....:       |:.::|:|.: |                |...|
Yeast   384 IFLVERYGRRRCLLWGAASMTACMV-------VFASVGVTRL-WPNGKKNGSSKGAGNCMIVFTC 440

  Fly   391 IAIFVGCYTAGVGSLTWVLNAELLVRPMRPLGCSIVCAFNWLTAFF-----------VICWFGSH 444
            ..:|  |:......:.:|:|:|.....::....:|..|.||:..|.           :..::|
Yeast   441 FYLF--CFATTWAPIPFVVNSETFPLRVKSKCMAIAQACNWIWGFLIGFFTPFISGAIDFYYG-- 501

  Fly   445 GVKCQPYLFLLFAIIASLILLFSLIYIPETKKLSSAKI 482
                  |:|:...:.:...:.|   ::||||.|:..::
Yeast   502 ------YVFMGCLVFSYFYVFF---FVPETKGLTLEEV 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glut3	NP_536732.1	Sugar_tr	60..484	CDD:278511	97/496 (20%)
Glut3	NP_536732.1	MFS	63..>226	CDD:119392	30/194 (15%)
HXT4	NP_011960.2	Sugar_tr	74..534	CDD:395036	97/493 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342375
Domainoid	1	1.000	165	1.000	Domainoid score	I819
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	165	1.000	Inparanoid score	I1037
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
TreeFam	0	0.000	Not matched by this tool.
	5	4.880