DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Glut3 and HXT14

DIOPT Version :9

Sequence 1:	NP_536732.1	Gene:	Glut3 / 42036	FlyBaseID:	FBgn0015230	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_014081.1	Gene:	HXT14 / 855398	SGDID:	S000005262	Length:	540	Species:	Saccharomyces cerevisiae

Alignment Length:	510	Identity:	115/510 - (22%)
Similarity:	200/510 - (39%)	Gaps:	120/510 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 LYSNIGSFFFGIAVGWSGTAERSVMEQHSY---------------SFQPTELQWS---------- 95
            |..::|.|.||..:|..|.....|..|..:               :.:.|:||..
Yeast    65 LVISLGGFIFGWDIGTIGGMTNMVSFQEKFGTTNIIHDDETIFVSTKKLTDLQIGLIISIFNISC 129

  Fly    96 --GVCILLTLG------AALWCLPMGLMVRLLGCRRTILIQLLPNFLGWFLTVFARSVPMLYAGR 152
              |...|..:|      ..:|   ..|:|..:|    |.||:|.....:|||:          ||
Yeast   130 GVGALTLSKIGDWIGRKGGIW---FALVVYCIG----ITIQILSYGRWYFLTL----------GR 177

  Fly   153 FFLGMCGGAHCVVVPIYNAEISTTKKRGAMGVVFEGACICGVIYSFAMSLFLELRIINFV----- 212
            ...|:..|...|:||::.:|.|..|.||:|...::.....|::..         .|:||:
Yeast   178 AVTGIGVGVTTVLVPMFLSENSPLKIRGSMVSTYQLIVTFGILMG---------NILNFICERCY 233

  Fly   213 -----NLG-----------LLALGPLQILMPESPAYYVDHGN-IPRAEDSLRFLRGQKYDTRREI 260
                 |:.           .:.:|...:.:||||.|.....| :|.|:.|...:.|........|
Yeast   234 KDPTQNIAWQLPLFLGYIWAIIIGMSLVYVPESPQYLAKIKNDVPSAKYSFARMNGIPATDSMVI 298

  Fly   261 DFL------TRDPTESEREVRQGPLL---GFKY----KKVRRSLARSLAIALLQKLCGALIFIFY 312
            :|:      ..:..|:..|.::..|:   .|::    .|:...|...:.|...|:|.|...|.:|
Yeast   299 EFIDDLLENNYNNEETNNESKKQSLVKRNTFEFIMGKPKLWLRLIIGMMIMAFQQLSGINYFFYY 363

  Fly   313 GLNMLDCLRIRREF--GLILC----LGLILGFLACFFLVDRLGRRPLLIFSSAGIVFVSIYLGLH 371
            |.::...:.|:..:  .:||.    |..|||    .:.|::.|.:..|::.|..::|       :
Yeast   364 GTSVFKGVGIKDPYITSIILSSVNFLSTILG----IYYVEKWGHKTCLLYGSTNLLF-------Y 417

  Fly   372 FKVWMTMGL----TVMSWIALFCI-AIFVGCYTAGVGSLTWVLNAELLVRPMRPLGCSI-VCAF- 429
            ...:.|:|.    |..|.|.|..: ..|:..:...:|.:|:||.:||.  |:|....|: :|.|
Yeast   418 MMTYATVGTFGRETDFSNIVLIIVTCCFIFWFAITLGPVTFVLVSELF--PLRTRAISMAICTFI 480

  Fly   430 NWLTAFFVICWFGSHGVKCQPYLFLLFAIIASLILLFSLIYIPETKKLSSAKIQQ 484
            ||:..|.:.........|....|..:||.....:::||.|.:|||:|.:..:|.:
Yeast   481 NWMFNFLISLLTPMIVSKIDFKLGYIFAACLLALIIFSWILVPETRKKNEQEINK 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glut3	NP_536732.1	Sugar_tr	60..484	CDD:278511	114/504 (23%)
Glut3	NP_536732.1	MFS	63..>226	CDD:119392	43/216 (20%)
HXT14	NP_014081.1	MFS_HXT	62..537	CDD:340914	115/510 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	165	1.000	Domainoid score	I819
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
TreeFam	0	0.000	Not matched by this tool.
	3	2.900