DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Glut3 and HXT2

DIOPT Version :9

Sequence 1:	NP_536732.1	Gene:	Glut3 / 42036	FlyBaseID:	FBgn0015230	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_013724.1	Gene:	HXT2 / 855023	SGDID:	S000004613	Length:	541	Species:	Saccharomyces cerevisiae

Alignment Length:	567	Identity:	116/567 - (20%)
Similarity:	203/567 - (35%)	Gaps:	161/567 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IQDAEPVEPPQSSRKSGTWFAKRPSEMPERHVERAPVRQKINNVGLYKATLYSNIGSFFFGIAVG 70
            :|..|..|.|..::...|     .:|:|.:            .:..|...:...:...|.|...|
Yeast    24 VQKLETDESPIQTKSEYT-----NAELPAK------------PIAAYWTVICLCLMIAFGGFVFG 71

  Fly    71 WSGTAERSVMEQHSYSFQPTELQWSGVCIL-----------LTLGAALWCLPMGLMVRLLGCRRT 124
            |........:.|..:..:..:::..|...|           ..:|.|...|.:|.:..:.|.|..
Yeast    72 WDTGTISGFVNQTDFKRRFGQMKSDGTYYLSDVRTGLIVGIFNIGCAFGGLTLGRLGDMYGRRIG 136

  Fly   125 ILIQLLPNFLG----------WFLTVFARSVPMLYAGRFFLGMCGGAHCVVVPIYNAEISTTKKR 179
            ::..:|...:|          |:         ..:.||...||..|...|:.|...:|.:....|
Yeast   137 LMCVVLVYIVGIVIQIASSDKWY---------QYFIGRIISGMGVGGIAVLSPTLISETAPKHIR 192

  Fly   180 G----------AMGVVFEGACI----------------CGVIYSFAMSLFLELRIINFVNLGLLA 218
            |          .:| :|.|.|.                .|:.::||:          |:..|:|
Yeast   193 GTCVSFYQLMITLG-IFLGYCTNYGTKDYSNSVQWRVPLGLNFAFAI----------FMIAGML- 245

  Fly   219 LGPLQILMPESPAYYVDHGNIPRAEDSLRFLRGQKYDTRREIDFLTRDPT-----ESER---EVR 275
                  ::||||.:.|:.|   |.||:.|.|......|..:...:....|     |:||   ...
Yeast   246 ------MVPESPRFLVEKG---RYEDAKRSLAKSNKVTIEDPSIVAEMDTIMANVETERLAGNAS 301

  Fly   276 QGPLLGFKYKKVRRSLARSLAIALLQKLCGALIFIFYGLNMLDCLRIRREFGLILCLGLILGFLA 340
            .|.|...|...:.| :...:.|..||:|.|...|.:||..:.:.:.::..|...:.|| |:.|.:
Yeast   302 WGELFSNKGAILPR-VIMGIMIQSLQQLTGNNYFFYYGTTIFNAVGMKDSFQTSIVLG-IVNFAS 364

  Fly   341 CF---FLVDRLGRRPLLIFSSAGIVFVSIYLGLHFKVWMTMGLT-----------------VMSW 385
            .|   :.||:.|||..|:..||.       :.:.|.::.|:|:|                 ||
Yeast   365 TFVALYTVDKFGRRKCLLGGSAS-------MAICFVIFSTVGVTSLYPNGKDQPSSKAAGNVM-- 420

  Fly   386 IALFCIAIFVGCYTAGVGSLTWVLNAELLVRPMRPL-----GCSIVCAFNWLTAF-------FVI 438
            |...|:.||       ..:::|...|.::|....||     ..:|....||:..|       |:.
Yeast   421 IVFTCLFIF-------FFAISWAPIAYVIVAESYPLRVKNRAMAIAVGANWIWGFLIGFFTPFIT 478

  Fly   439 CWFG-SHGVKCQPYLFLLFAIIASLILLFSLIYIPETKKLSSAKIQQ 484
            ...| |:|     |:|:...:.:...:.|   ::.|||.|:..::.:
Yeast   479 SAIGFSYG-----YVFMGCLVFSFFYVFF---FVCETKGLTLEEVNE 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glut3	NP_536732.1	Sugar_tr	60..484	CDD:278511	108/511 (21%)
Glut3	NP_536732.1	MFS	63..>226	CDD:119392	36/209 (17%)
HXT2	NP_013724.1	Sugar_tr	59..519	CDD:395036	108/515 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342374
Domainoid	1	1.000	165	1.000	Domainoid score	I819
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	165	1.000	Inparanoid score	I1037
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
TreeFam	0	0.000	Not matched by this tool.
	5	4.880