DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Glut3 and GEX2

DIOPT Version :9

Sequence 1:	NP_536732.1	Gene:	Glut3 / 42036	FlyBaseID:	FBgn0015230	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_013032.1	Gene:	GEX2 / 853981	SGDID:	S000001814	Length:	615	Species:	Saccharomyces cerevisiae

Alignment Length:	552	Identity:	111/552 - (20%)
Similarity:	179/552 - (32%)	Gaps:	205/552 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 RKGGI-QDAEPVEPPQSSR-----KSGTWFAKRPSEMPERHVERAPVRQKINNVGLYKATLYSNI 60
            :|.|| |..|.:|..:.|.     .:.|:|..:.:|:.....:...          ||..|.|..
Yeast    12 KKSGIRQSCEIIERERHSNDDTYSMTSTFFKLKENEIMSAQFDSLK----------YKILLISTA 66

  Fly    61 GSFFFGIAVG------WSGTAERSVMEQHSYSFQPTELQWSGVCILLTLGAALWCLPMGLMV--- 116
            ....|||::.      ::|.|..|..| ||              :|.|:......:.:|..|
Yeast    67 FVCGFGISLDYTLRSTYTGYATNSYSE-HS--------------LLSTVQVINAVVSVGSQVVYS 116

  Fly   117 RL---LGCRRTILIQLLPNFLGWFLTVFARSVPMLYAGRFFLGMCG--GAHCVVVPIYNAEISTT 176
            ||   .|..|..|:..:...:|..:...|..:.|..||..|.. ||  |.:.::..|. ::.|:.
Yeast   117 RLSDHFGRLRLFLVATIFYIMGTIIQSQATRLTMYAAGSVFYN-CGYVGTNLLLTLIL-SDFSSL 179

  Fly   177 KKRGAMGVVFEGACICGVIYSFAMSLFLELRIINFVNLGLL-ALGPLQ-----ILMPESPAYYVD 235
            |.|              :.|.:|.  :....||.:::..:: |..|.:     |.|   .|:...
Yeast   180 KWR--------------MFYQYAS--YWPYIIIPWISGNIITAANPQKNWSWNIAM---WAFIYP 225

  Fly   236 HGNIPRAEDSLRFLRGQKYDTRREIDFLTRDPTESEREVRQGPLLGFKYKKVRRSLARSLAIALL 300
            ...:|                   |.||               :|..|||..:.:..|||.....
Yeast   226 LSTLP-------------------IIFL---------------ILYMKYKSSKTAEWRSLKEQAR 256

  Fly   301 QKLCGA----LIFIFYGLNMLDCLRIRREFGLIL------------------CLGLILGFLACFF 343
            ::..|.    |:|:|:.|:::..|.|....|.||                  ...|:.|  .|.|
Yeast   257 KERTGGLFENLVFLFWKLDIVGILLITVSLGCILVPLTLANETSQKWHNSKIIATLVSG--GCLF 319

  Fly   344 LV-----DRLGRRPLLIF---SSAGIVFVSIYLGLHFKVWMTMGLTVMSWIALFCIAIFVGC--- 397
            .:     .:..:.|||.|   |..||             |..:|:|..::     ...|:.|
Yeast   320 FIFLYWEAKFAKSPLLPFKLLSDRGI-------------WAPLGVTFFNF-----FTFFISCDYL 366

  Fly   398 -----------------------YTAGVGSLTWVLNAELLVRPMRPLGCSIV--CAFNWLTAFFV 437
                                   :.|...|..:    .|||...|.|..|::  || .|:....:
Yeast   367 YPVLLVSMKESSTSAARIVNLPDFVAATASPFY----SLLVAKTRKLKLSVIGGCA-AWMVCMGL 426

  Fly   438 ICWF----GSH-GVKCQPYLFLLFAIIASLIL 464
            ...:    ||| ||           |.||:|:
Yeast   427 FYKYRGGSGSHEGV-----------IAASVIM 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glut3	NP_536732.1	Sugar_tr	60..484	CDD:278511	97/488 (20%)
Glut3	NP_536732.1	MFS	63..>226	CDD:119392	38/182 (21%)
GEX2	NP_013032.1	MFS_ARN_like	59..571	CDD:340880	100/495 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900