DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Glut3 and AZR1

DIOPT Version :9

Sequence 1:	NP_536732.1	Gene:	Glut3 / 42036	FlyBaseID:	FBgn0015230	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_011740.3	Gene:	AZR1 / 853139	SGDID:	S000003456	Length:	613	Species:	Saccharomyces cerevisiae

Alignment Length:	568	Identity:	98/568 - (17%)
Similarity:	196/568 - (34%)	Gaps:	173/568 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 EPPQSSRKSGTWFAKRPSEMPERHVERAPVRQKI------NNVG------------------LYK 53
            ||...|....:::.::..:..|:..::..||:..      .||.                  ||.
Yeast     4 EPKTYSMSDLSYYGEKAQQQNEKQQKQYVVRRNSTQSTSKQNVSVVLEDNASESNELPKGFILYA 68

  Fly    54 ATLYSNIGSFFFGIAVGWSGTAERSVMEQH-SYSFQPTELQW--SGVCILLTLGAALWCLPMGLM 115
            :.:...:..|...:.:....|....|.:|. |||    |:.|  :|..:...|.|.:|    |.:
Yeast    69 SLIALALSLFLAALDIMIVSTIIEEVAKQFGSYS----EIGWLFTGYSLPNALLALIW----GRI 125

  Fly   116 VRLLGCRRTILIQLLPNFLGWFLTVFARSVPMLYAGRFFLGMCG-GAHCVVVPIYNAEISTTKKR 179
            ...:|.:.|:|..::...:|..::..|.|:.||..||...|:.| |...:...|.:..:..:::.
Yeast   126 ATPIGFKETMLFAIVIFEIGSLISALANSMSMLIGGRVIAGVGGCGIQSLSFVIGSTLVEESQRG 190

  Fly   180 GAMGVVFEGACICGVIYSFAMSLF---LELRIINFVNLGLLALGPLQILMPESPAYYVDHGNIPR 241
            ..:.|:.....|..|:..|...:|   :..|...:|||.:..|.....|...:|..    .....
Yeast   191 ILIAVLSCSFAIASVVGPFLGGVFTSSVTWRWCFYVNLPIGGLAFFLFLFFYNPGL----STFQE 251

  Fly   242 AEDSLRFLRGQKYDTRREIDFLTRDPTESEREVRQGPLLGFKYKKVRRSLARSLAIALLQ----- 301
            ..|::|                                   |:......:.|::|..||:
Yeast   252 TMDNIR-----------------------------------KFPSQFIEIVRNVAYHLLKIKGFS 281

  Fly   302 KLCG------ALIFIFYGLNML------DCLRIRREFG------------LILCLGLILGFLACF 342
            ||.|      .|||::..:..:      .|:.:...||            ::..:|::|..||
Yeast   282 KLNGWRKPFMELIFMYDIIEFVFCSAGFTCILLAFTFGGNRYAWNSASIIILFIIGIVLVVLA-- 344

  Fly   343 FLVDRLGRRPLLIFSSAGIVFVSIYLGLHFKVWMTMGLTVMSW-------IALFCIAIFVGCYTA 400
                  |....|:|....||..:    .|::       .:|||       |....||:|:.|  |
Yeast   345 ------GIYDFLVFPKFNIVKAT----PHYQ-------PLMSWTNIKKPGIFTVNIALFLTC--A 390

  Fly   401 GVGSLTWVLNAELLVRPMRPLGCSIVCAFNWLTAFFVICWFGS------HGVKCQPYLFLLFAII 459
            |                       .:..|.::..:|.:.:..|      |.|.|      :.:.:
Yeast   391 G-----------------------YISQFTYIVQYFQLIYNDSAWRAAVHLVAC------IISTV 426

  Fly   460 ASLILLFSLIYIPETKKLSSAKIQQRLGGLINRPAVITFTSSSDSSNA 507
            .:.||..::  ..:|:::....:...:.|::. ..::|..:::.:::|
Yeast   427 VTAILCGAI--TDKTRQIKPIIVISSIFGVVG-AGILTLLNNNANNSA 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glut3	NP_536732.1	Sugar_tr	60..484	CDD:278511	85/472 (18%)
Glut3	NP_536732.1	MFS	63..>226	CDD:119392	38/169 (22%)
AZR1	NP_011740.3	MFS_Azr1_MDR_like	83..540	CDD:341045	87/489 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900