DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Glut3 and Slc2a8

DIOPT Version :9

Sequence 1:	NP_536732.1	Gene:	Glut3 / 42036	FlyBaseID:	FBgn0015230	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_445946.2	Gene:	Slc2a8 / 85256	RGDID:	620611	Length:	478	Species:	Rattus norvegicus

Alignment Length:	482	Identity:	121/482 - (25%)
Similarity:	212/482 - (43%)	Gaps:	55/482 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 RAPVRQKINNVGLYKATLYSNIGSFFFGIAVGWSGTAERSVMEQHSYSFQ--PTELQWSGVCILL 101
            |||..:::     :.||..:.:|...||.|:|:|..|..|:......:.:  .|...|.|.  ::
  Rat    19 RAPGGRRV-----FLATFAAALGPLSFGFALGYSSPAIPSLRRTAPPALRLGDTAASWFGA--VV 76

  Fly   102 TLGAALWCLPMGLMVRLLGCRRTILIQLLPNFLGWFLTVFARSVPMLYAGRFFLGMCGGAHCVVV 166
            |||||...:..|.::...|.:.::|:..:|...|:.:...||.|.||..||...|:..|...:|.
  Rat    77 TLGAAAGGVLGGWLLDRAGRKLSLLLCTVPFVTGFAVITAARDVWMLLGGRLLTGLACGVASLVA 141

  Fly   167 PIYNAEISTTKKRGAMGVVFEGACICGVIYSFAMSLFLE---LRIINFVNLGLLALGPLQILMPE 228
            |:|.:||:....||.:|...:...:.|::.::.....||   |.::..|...|:.|  |...|||
  Rat   142 PVYISEIAYPAVRGLLGSCVQLMVVTGILLAYVAGWVLEWRWLAVLGCVPPTLMLL--LMCYMPE 204

  Fly   229 SPAYYVDHGNIPRAEDSLRFLRGQKYDTRREIDFLTRDPTESEREVRQGPLLGFKYKKVRR---- 289
            :|.:.:.......|..:||||.|.:       :.....|..:|.:       ||:...:||
  Rat   205 TPRFLLTQHQYQEAMAALRFLWGSE-------EGWEEPPVGAEHQ-------GFQLAMLRRPGVH 255

  Fly   290 -SLARSLAIALLQKLCGALIFIFYGLNMLDCLRIRREFGLILCLGLI--LGFLACFFLVDRLGRR 351
             .|...:.:.:.|:|.|....:||...:.:..:.:......:.:|:|  |.......::||.||:
  Rat   256 KPLIIGICLMVFQQLSGVNAIMFYANTIFEEAKFKDSSLASVTVGIIQVLFTAVAALIMDRAGRK 320

  Fly   352 PLLIFSSAGIVFVSIYLGLHFKVWMT-------MGLTV------------MSWIALFCIAIFVGC 397
            .||..|...:||.....|.:||:..:       :||.|            ::|:|:..:.:|:..
  Rat   321 LLLALSGVIMVFSMSAFGTYFKLTQSGPSNSSHVGLLVPISAEPADVHLGLAWLAVGSMCLFIAG 385

  Fly   398 YTAGVGSLTWVLNAELLVRPMRPLGCSIVCAFNWLTAFFVICWFGSHGVKCQPY-LFLLFAIIAS 461
            :..|.|.:.|:|.:|:....::.:...:....||..||.|...|.|.....:|| .|.|.|....
  Rat   386 FAVGWGPIPWLLMSEIFPLHIKGVATGVCVLTNWFMAFLVTKEFNSIMEILRPYGAFWLTAAFCI 450

  Fly   462 LILLFSLIYIPETKKLSSAKIQQRLGG 488
            |.:||:|.::||||..:..:|.....|
  Rat   451 LSVLFTLTFVPETKGRTLEQITAHFEG 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glut3	NP_536732.1	Sugar_tr	60..484	CDD:278511	115/455 (25%)
Glut3	NP_536732.1	MFS	63..>226	CDD:119392	45/167 (27%)
Slc2a8	NP_445946.2	Dileucine internalization motif. /evidence=ECO:0000269\|PubMed:10671487	12..13
		MFS	27..470	CDD:421695	116/460 (25%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	268..274		3/5 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337781
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52445
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	1	1.000	-	-		FOG0000275
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48021
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860