DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Glut3 and ITR1

DIOPT Version :9

Sequence 1:	NP_536732.1	Gene:	Glut3 / 42036	FlyBaseID:	FBgn0015230	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_010785.1	Gene:	ITR1 / 852108	SGDID:	S000002905	Length:	584	Species:	Saccharomyces cerevisiae

Alignment Length:	521	Identity:	117/521 - (22%)
Similarity:	212/521 - (40%)	Gaps:	77/521 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 AKRPSEMPERH-VERAPV-----RQKINNVG------------------LYKATLYSNIGSFFFG 66
            :||.....|.| ::|||.     |.:|..|.                  :...|..::|..|.||
Yeast    37 SKRGKITLESHEIQRAPASDDEDRIQIKPVNDEDDTSVMITFNQSLSPFIITLTFVASISGFMFG 101

  Fly    67 IAVGWSGTAERSV---MEQHSYSFQPTELQWSGVCILLTLGAALWCLPMGLMVRLLGCRRTILIQ 128
            ...|:..:|..|:   ::....::...|:    |....:|||.:..:..|....:.|.:|.::..
Yeast   102 YDTGYISSALISIGTDLDHKVLTYGEKEI----VTAATSLGALITSIFAGTAADIFGRKRCLMGS 162

  Fly   129 LLPNFLGWFLTVFARSVPMLYAGRFFLGMCGGAHCVVVPIYNAEISTTKKRGAMGVVFEGACICG 193
            .|...:|..|.|.|.:...:..||..:|...|...::.|::.:||:....||.:.|:.......|
Yeast   163 NLMFVIGAILQVSAHTFWQMAVGRLIMGFGVGIGSLIAPLFISEIAPKMIRGRLTVINSLWLTGG 227

  Fly   194 VIYSFAMSLFLELRIINFVNLGLLALGPLQIL-----------MPESPAYYVDHGNIPRAEDSLR 247
            .:.::.....|     |:||.|...|..|.::           :|::|.|||..|::.||.:.|:
Yeast   228 QLVAYGCGAGL-----NYVNNGWRILVGLSLIPTAVQFTCLCFLPDTPRYYVMKGDLARATEVLK 287

  Fly   248 FLRGQKY-DTRREI------DFLTRDPTESEREVRQGPLLGFKYKKVRRSLARSLAIA----LLQ 301
                :.| ||..||      :.:|.:.:...:.|.:......|......|..|:|.|.    .:|
Yeast   288 ----RSYTDTSEEIIERKVEELVTLNQSIPGKNVPEKVWNTIKELHTVPSNLRALIIGCGLQAIQ 348

  Fly   302 KLCGALIFIFYGLNMLDCLRIRREFGL-ILCLGLILGF-LACFFLVDRLGRRPLLIFSSAG---- 360
            :..|....:::...:.:.:..:....: |:..|....| |..||.:|::|||.:|:....|
Yeast   349 QFTGWNSLMYFSGTIFETVGFKNSSAVSIIVSGTNFIFTLVAFFSIDKIGRRTILLIGLPGMTMA 413

  Fly   361 IVFVSI---YLGLHF----KVWMTMGLTVMSWIALFCIAIFVGCYTAGVGSLTWVLNAELLVRPM 418
            :|..||   :||:.|    .|.::.|.:....:.:..|.:|...|..|:|::.| ..:||..:.:
Yeast   414 LVVCSIAFHFLGIKFDGAVAVVVSSGFSSWGIVIIVFIIVFAAFYALGIGTVPW-QQSELFPQNV 477

  Fly   419 RPLGCSIVCAFNWLTAFFVICWFGSHGVKCQPY-LFLLFAIIASLILLFSLIYIPETKKLSSAKI 482
            |.:|.|...|.||..:..:...|.:......|. .|..||.::.|..:|.....||...|...::
Yeast   478 RGIGTSYATATNWAGSLVIASTFLTMLQNITPAGTFAFFAGLSCLSTIFCYFCYPELSGLELEEV 542

  Fly   483 Q 483
            |
Yeast   543 Q 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glut3	NP_536732.1	Sugar_tr	60..484	CDD:278511	106/463 (23%)
Glut3	NP_536732.1	MFS	63..>226	CDD:119392	37/176 (21%)
ITR1	NP_010785.1	MFS_HMIT_like	92..533	CDD:340918	102/454 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342335
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740