DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Glut3 and HXT3

DIOPT Version :9

Sequence 1:	NP_536732.1	Gene:	Glut3 / 42036	FlyBaseID:	FBgn0015230	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_010632.1	Gene:	HXT3 / 851946	SGDID:	S000002753	Length:	567	Species:	Saccharomyces cerevisiae

Alignment Length:	549	Identity:	111/549 - (20%)
Similarity:	212/549 - (38%)	Gaps:	113/549 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VEPPQSSRKSGTWFAKRPSE---MP-ERHVE---RAPVRQKINN----VGLYKATLYSNIGSFFF 65
            :.|.:||..|........|:   || |:.|:   :|...|.:.|    .|.|.......:...|.
Yeast     8 ISPQKSSENSNADLPSNSSQVMNMPEEKGVQDDFQAEADQVLTNPNTGKGAYVTVSICCVMVAFG 72

  Fly    66 GIAVGW-SGT----------AERSVMEQHSYSFQPTELQWSGVCILLTLGAALWCLPMGLMVRLL 119
            |...|| :||          ..|..|:....|:..::::...:..:..:|.|:..:.:..:..:.
Yeast    73 GFVFGWDTGTISGFVAQTDFLRRFGMKHKDGSYYLSKVRTGLIVSIFNIGCAIGGIILAKLGDMY 137

  Fly   120 GCRRTILIQLLPNFLG----------WFLTVFARSVPMLYAGRFFLGMCGGAHCVVVPIYNAEIS 174
            |.:..:::.::...:|          |:         ..:.||...|:..|...|:.|:..:|::
Yeast   138 GRKMGLIVVVVIYIIGIIIQIASINKWY---------QYFIGRIISGLGVGGIAVLSPMLISEVA 193

  Fly   175 TTKKRGAMGVVFEGACICGVIYSFAMSLFLELRIINFVN-------LGLLALGPLQIL-----MP 227
            ..:.||.:...::.....|:...:..:...:    |:.|       |||.....|.::     :|
Yeast   194 PKEMRGTLVSCYQLMITLGIFLGYCTNFGTK----NYSNSVQWRVPLGLCFAWALFMIGGMTFVP 254

  Fly   228 ESPAYYVDHGNIPRAEDSLRFLRGQKYD---TRREIDFLTRDPTESER--EVRQGPLLGFKYKKV 287
            |||.|.|:.|.|..|..||..:.....|   .::|::.:.....|:..  ....|.|...|....
Yeast   255 ESPRYLVEAGQIDEARASLSKVNKVAPDHPFIQQELEVIEASVEEARAAGSASWGELFTGKPAMF 319

  Fly   288 RRSLARSLAIALLQKLCGALIFIFYGLNMLDCLRIRREFGLILCLGLILGFLAC--FFLVDRLGR 350
            :|:: ..:.|..||:|.|...|.:||..:.:.:.:...|...:..|::..|..|  .:.|||.||
Yeast   320 KRTM-MGIMIQSLQQLTGDNYFFYYGTTVFNAVGMSDSFETSIVFGVVNFFSTCCSLYTVDRFGR 383

  Fly   351 RPLLIFSSAGIVFVSIYLGLHFKVWMTMGLTVMSW----------------IALFCIAIFVGCYT 399
            |..|::.:.|:|..       :.|:.::|:|.: |                |...|..||  |:.
Yeast   384 RNCLLYGAIGMVCC-------YVVYASVGVTRL-WPNGEGNGSSKGAGNCMIVFACFYIF--CFA 438

  Fly   400 AGVGSLTWVLNAELLVRPMRPLGCSIVCAFNWLTAFF-----------VICWFGSHGVKCQPYLF 453
            .....:.:|:.:|.....::....||..|.|||..|.           :..::|        |:|
Yeast   439 TTWAPIAYVVISETFPLRVKSKAMSIATAANWLWGFLIGFFTPFITGAINFYYG--------YVF 495

  Fly   454 LLFAIIASLILLFSLIYIPETKKLSSAKI 482
            :...:.|...:.|   ::||||.|:..::
Yeast   496 MGCMVFAYFYVFF---FVPETKGLTLEEV 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glut3	NP_536732.1	Sugar_tr	60..484	CDD:278511	97/490 (20%)
Glut3	NP_536732.1	MFS	63..>226	CDD:119392	30/195 (15%)
HXT3	NP_010632.1	Sugar_tr	65..525	CDD:395036	97/492 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342370
Domainoid	1	1.000	165	1.000	Domainoid score	I819
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	165	1.000	Inparanoid score	I1037
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
TreeFam	0	0.000	Not matched by this tool.
	5	4.880