DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Glut3 and HXT6

DIOPT Version :9

Sequence 1:	NP_536732.1	Gene:	Glut3 / 42036	FlyBaseID:	FBgn0015230	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_010630.1	Gene:	HXT6 / 851944	SGDID:	S000002751	Length:	570	Species:	Saccharomyces cerevisiae

Alignment Length:	561	Identity:	111/561 - (19%)
Similarity:	210/561 - (37%)	Gaps:	127/561 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IQDAEPVEPPQSSRKSGTWFAKRPSEMPERHVERA----PVRQKINNVGLYKATLYSNIGSF--- 63
            |.:..|||...:...:.......||...||...:|    ...:.:..:....|:.|..:...
Yeast     7 IAEQTPVEHLSAVDSASHSVLSTPSNKAERDEIKAYGEGEEHEPVVEIPKRPASAYVTVSIMCIM 71

  Fly    64 --FFGIAVGW-SGT----------AERSVMEQHSYSFQPTELQWSGVCILLTLGAALWCLPMGLM 115
              |.|...|| :||          ..|..|:....:...::::...:..:..:|.|:..:.:..:
Yeast    72 IAFGGFVFGWDTGTISGFINQTDFIRRFGMKHKDGTNYLSKVRTGLIVSIFNIGCAIGGIILSKL 136

  Fly   116 VRLLGCRRTILIQLLPNFLG----------WFLTVFARSVPMLYAGRFFLGMCGGAHCVVVPIYN 170
            ..:.|.:..:::.::...:|          |:         ..:.||...|:..|...|:.|:..
Yeast   137 GDMYGRKVGLIVVVVIYIIGIIIQIASINKWY---------QYFIGRIISGLGVGGIAVLSPMLI 192

  Fly   171 AEISTTKKRGAMGVVFEGACICGVIYSFAMSLFLELRIINFVN-------LGLLALGPLQIL--- 225
            :|:|....||.:...::.....|:...:..:...:    |:.|       |||.....|.::
Yeast   193 SEVSPKHLRGTLVSCYQLMITAGIFLGYCTNFGTK----NYSNSVQWRVPLGLCFAWALFMIGGM 253

  Fly   226 --MPESPAYYVDHGNIPRAEDSLRFLRGQKYDTRREIDFLTRDPT------------ESER---E 273
              :||||.|..:.|.|..|:.|:........|          ||:            |:|:   .
Yeast   254 TFVPESPRYLAEVGKIEEAKRSIAVSNKVAVD----------DPSVLAEVEAVLAGVEAEKLAGN 308

  Fly   274 VRQGPLLGFKYKKVRRSLARSLAIALLQKLCGALIFIFYGLNMLDCLRIRREFGLILCLGLILGF 338
            ...|.|...|.|.::| |.....|..||:|.|...|.:||..:...:.:...|...:.|| |:.|
Yeast   309 ASWGELFSSKTKVLQR-LIMGAMIQSLQQLTGDNYFFYYGTTIFKAVGLSDSFETSIVLG-IVNF 371

  Fly   339 LACF---FLVDRLGRRPLLIFSSAGIVFVSIYLGLHFKVWMTMGLTVMSW--------------- 385
            .:.|   ::|:|.|||..|::.:|.:....:       |:.::|:|.: |
Yeast   372 ASTFVGIYVVERYGRRTCLLWGAASMTACMV-------VYASVGVTRL-WPNGQDQPSSKGAGNC 428

  Fly   386 -IALFCIAIFVGCYTAGVGSLTWVLNAELLVRPMRPLGCSIVCAFNWLTAFFVICWFGSHGVKCQ 449
             |...|..||  |:......:.:|:.:|.....::....||..|.|||.. |:|.:|       .
Yeast   429 MIVFACFYIF--CFATTWAPIPYVVVSETFPLRVKSKAMSIATAANWLWG-FLIGFF-------T 483

  Fly   450 PYL------FLLFAIIASLILLF--SLIYIPETKKLSSAKI 482
            |::      :..:..:..|:.:|  .|:.:||||.|:..::
Yeast   484 PFITGAINFYYGYVFMGCLVFMFFYVLLVVPETKGLTLEEV 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glut3	NP_536732.1	Sugar_tr	60..484	CDD:278511	100/503 (20%)
Glut3	NP_536732.1	MFS	63..>226	CDD:119392	30/200 (15%)
HXT6	NP_010630.1	Sugar_tr	68..528	CDD:278511	100/500 (20%)
HXT6	NP_010630.1	MFS	69..514	CDD:119392	95/487 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342378
Domainoid	1	1.000	165	1.000	Domainoid score	I819
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	165	1.000	Inparanoid score	I1037
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
TreeFam	0	0.000	Not matched by this tool.
	5	4.880