DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Glut3 and HXT15

DIOPT Version :9

Sequence 1:	NP_536732.1	Gene:	Glut3 / 42036	FlyBaseID:	FBgn0015230	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_010036.1	Gene:	HXT15 / 851352	SGDID:	S000002404	Length:	567	Species:	Saccharomyces cerevisiae

Alignment Length:	529	Identity:	111/529 - (20%)
Similarity:	210/529 - (39%)	Gaps:	88/529 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VEPPQSSRKSGTWFAKRPSEMPERHVERAPVRQKINNVGLYKATLYSNIGSFF----FGIAVGWS 72
            |:||.....|..::.|   |:...:...||.|..:..:.:|......:.|.|.    .||..|:.
Yeast    24 VQPPGEKEWSDGFYDK---EVINGNTPDAPKRGFLGYLIIYLLCYPVSFGGFLPGWDSGITAGFI 85

  Fly    73 GTAERSVMEQHSYSFQPTELQWSGV-----CILLTLGAALWCLPMGLMVRLLGCRRTILIQLLPN 132
             ..:...|...||.....|...|.|     ..:.::|.::..:....:...||.|..|:|.:|..
Yeast    86 -NMDNFKMNFGSYKHSTGEYYLSNVRMGLLVAMFSVGCSIGGVAFARLADTLGRRLAIVIVVLVY 149

  Fly   133 FLG----------WFLTVFARSVPMLYAGRFFLGMCGGAHCVVVPIYNAEISTTKKRGAMGVVFE 187
            .:|          |:         ..:.|:...|:..|...|:.|:..:||:.|..||.:..:::
Yeast   150 MVGAIIQISSNHKWY---------QYFVGKIIYGLGAGGCSVLCPMLLSEIAPTDLRGGLVSLYQ 205

  Fly   188 GACICGVIYSFAMSLFLELRIINF----VNLGLLALGPL-----QILMPESPAYYVDHGNIPRAE 243
            .....|:...:. |::...:..|.    :.:||..|..|     .:|:||||.|.::   ..|.|
Yeast   206 LNMTFGIFLGYC-SVYGTRKYSNTAQWRIPVGLCFLWALIIIVGMLLVPESPRYLIE---CERHE 266

  Fly   244 DS-LRFLRGQKYDTRREIDFLTRDPTE------SEREVRQG---PLLGFKYKKVRRSLARSLAIA 298
            :: :...:..|...  |..::.:...|      ::||:.:.   .|...|.|.::|.:...|...
Yeast   267 EACVSIAKINKVSP--EDPWVLKQADEINAGVLAQRELGEASWKELFSVKTKVLQRLITGILVQT 329

  Fly   299 LLQKLCGALIFIFYGLNMLDCLRIRREFGLILCLGLILGF--LACFFLVDRLGRRPLLIFSSAGI 361
            .|| |.|...|.|||..:...:.:...|...:.||.:..|  :....:||::|||..|:|.:|.:
Yeast   330 FLQ-LTGENYFFFYGTTIFKSVGLTDGFETSIVLGTVNFFSTIIAVMVVDKIGRRKCLLFGAASM 393

  Fly   362 VFVSIYLGLHFKVWMTMGLTVM---------------SWIALFCIAIFVGCYTAGVGSLTWVLNA 411
            :...:       ::.::|:..:               :.|...|..||  |:......:.:::.|
Yeast   394 MACMV-------IFASIGVKCLYPHGQDGPSSKGAGNAMIVFTCFYIF--CFATTWAPVAYIVVA 449

  Fly   412 ELLVRPMRPLGCSIVCAFNWLTAFFVICWFGSHGVKCQPYLFLLFAIIASLILLFSLI--YIPET 474
            |.....::....||..|||||..|.:  .|.:..:....:.:..:..:..|:.:|..:  ::|||
Yeast   450 ESFPSKVKSKAMSISTAFNWLWQFLI--GFFTPFITGSIHFYYGYVFVGCLVAMFLYVFFFLPET 512

  Fly   475 KKLSSAKIQ 483
            ..||..:||
Yeast   513 IGLSLEEIQ 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glut3	NP_536732.1	Sugar_tr	60..484	CDD:278511	101/481 (21%)
Glut3	NP_536732.1	MFS	63..>226	CDD:119392	36/190 (19%)
HXT15	NP_010036.1	MFS_HXT	62..524	CDD:340914	101/488 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342379
Domainoid	1	1.000	165	1.000	Domainoid score	I819
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	165	1.000	Inparanoid score	I1037
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
TreeFam	0	0.000	Not matched by this tool.
	6	5.790