DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Glut3 and SNF3

DIOPT Version :9

Sequence 1:	NP_536732.1	Gene:	Glut3 / 42036	FlyBaseID:	FBgn0015230	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_010087.1	Gene:	SNF3 / 851333	SGDID:	S000002353	Length:	884	Species:	Saccharomyces cerevisiae

Alignment Length:	534	Identity:	133/534 - (24%)
Similarity:	218/534 - (40%)	Gaps:	80/534 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 GGIQDAEPVEPPQSSRKSG--TWFAKRPSEMPERHV--ERAPVRQKINN---VGLYKATLYSNIG 61
            |.|:....::...|.|:|.  :.|....|.:.:..:  ...|.:|.:..   ||::.|     :|
Yeast    48 GSIRTPTSLQRQNSDRQSNMTSVFTDDISTIDDNSILFSEPPQKQSMMMSICVGVFVA-----VG 107

  Fly    62 SFFFGIAVGWSGT------AERSVMEQHSYSFQPTELQWSGVCILLTLGAALWCLPMGLMVRLLG 120
            .|.||...|...:      .:..|...|. ||  |..|.|.:...|:||.....|....:....|
Yeast   108 GFLFGYDTGLINSITSMNYVKSHVAPNHD-SF--TAQQMSILVSFLSLGTFFGALTAPFISDSYG 169

  Fly   121 CRRTILIQLLPNF-LGWFLTVFARSVPMLYAGRFFLGMCGGAHCVVVPIYNAEISTTKKRGAMGV 184
            .:.||:...:..| :|..|.|.|..:.:|..||...|:..||...|||:|.||.:....|||:..
Yeast   170 RKPTIIFSTIFIFSIGNSLQVGAGGITLLIVGRVISGIGIGAISAVVPLYQAEATHKSLRGAIIS 234

  Fly   185 VFEGACICGVIYSFAMSLFLELRI----------INFVNLGLLALGPLQILMPESPAYYVDHGNI 239
            .::.|...|::.|.|:|.....|.          :.:|....||:|  ...:||||.|||....:
Yeast   235 TYQWAITWGLLVSSAVSQGTHARNDASSYRIPIGLQYVWSSFLAIG--MFFLPESPRYYVLKDKL 297

  Fly   240 PRAEDSLRFLRGQKYDTRREIDFLTRDPTESEREVRQGP------LLGFKYKKVRRSLARSLAIA 298
            ..|..||.||||........::.|.......:.|...|.      .:..| .:.:::|.....||
Yeast   298 DEAAKSLSFLRGVPVHDSGLLEELVEIKATYDYEASFGSSNFIDCFISSK-SRPKQTLRMFTGIA 361

  Fly   299 L--LQKLCGALIFIFYGLNMLDCLRIRREF---GLILCLGLILGFLACFFLVDRLGRRPLLIFSS 358
            |  .|:..|.....:||:|..:...:...:   .:...:.::......|| |:..|||.:|:.
Yeast   362 LQAFQQFSGINFIFYYGVNFFNKTGVSNSYLVSFITYAVNVVFNVPGLFF-VEFFGRRKVLVV-- 423

  Fly   359 AGIV-----FVSIYLGLHFKVWMTMGLTVMSWIALFCIAIFVGCYTAGVGSLTWVLNAELLVRPM 418
            .|::     |:...:|...|.  .....||  ||..|  :|:..::|..|.:.||::|||.
Yeast   424 GGVIMTIANFIVAIVGCSLKT--VAAAKVM--IAFIC--LFIAAFSATWGGVVWVISAELY---- 478

  Fly   419 RPLG----CSIVC-AFNWLTAFFVICWF--------GSHGVKCQPYLFLLFAIIASLILLFSLIY 470
             |||    |:.:| |.|||..|  ||..        |||.......:|.::..:.::.::...:.
Yeast   479 -PLGVRSKCTAICAAANWLVNF--ICALITPYIVDTGSHTSSLGAKIFFIWGSLNAMGVIVVYLT 540

  Fly   471 IPETKKLSSAKIQQ 484
            :.|||.|:..:|.:
Yeast   541 VYETKGLTLEEIDE 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glut3	NP_536732.1	Sugar_tr	60..484	CDD:278511	121/469 (26%)
Glut3	NP_536732.1	MFS	63..>226	CDD:119392	48/179 (27%)
SNF3	NP_010087.1	MFS_HXT	99..556	CDD:340914	124/483 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342339
Domainoid	1	1.000	165	1.000	Domainoid score	I819
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
TreeFam	0	0.000	Not matched by this tool.
	4	3.830