DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Glut3 and HXT10

DIOPT Version :9

Sequence 1:	NP_536732.1	Gene:	Glut3 / 42036	FlyBaseID:	FBgn0015230	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_116644.1	Gene:	HXT10 / 850536	SGDID:	S000001883	Length:	546	Species:	Saccharomyces cerevisiae

Alignment Length:	514	Identity:	108/514 - (21%)
Similarity:	194/514 - (37%)	Gaps:	154/514 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 FFGIAVGW-SGTAERSVME----------QHSYSFQPTELQWSGVCILLTLGAALWCLPMGLMVR 117
            |.|...|| :||....:.:          |...|||.::::...:..:..:|.||..|.:|.:..
Yeast    58 FGGFIFGWDTGTISGFINQTDFKRRFGELQRDGSFQLSDVRTGLIVGIFNIGCALGGLTLGRLGD 122

  Fly   118 LLGCRRTILIQLLPNFLG----------WFLTVFARSVPMLYAGRFFLGMCGGAHCVVVPIYNAE 172
            :.|.:..::..:|...:|          |:         ..:.||...||..|...|:.|...:|
Yeast   123 IYGRKIGLMCVILVYVVGIVIQIASSDKWY---------QYFIGRIVSGMGVGGVAVLSPTLISE 178

  Fly   173 ISTTKKRG----------AMGVVFEGACI----------------CGVIYSFAMSLFLELRIINF 211
            ||....||          .:| :|.|.|.                .|:.:::|:          |
Yeast   179 ISPKHLRGTCVSFYQLMITLG-IFLGYCTNYGTKKYSNSIQWRVPLGLCFAWAI----------F 232

  Fly   212 VNLGLLALGPLQILMPESPAYYVDHGNIPRAEDSLRFLRGQK-----------YDT---RREIDF 262
            :.:|:       :::||||.|.|:.|....|..||  .:..|           :||   ..|::.
Yeast   233 MVIGM-------VMVPESPRYLVEKGKYEEARRSL--AKSNKVTVTDPGVVFEFDTIVANMELER 288

  Fly   263 LTRDPTESEREVRQGPLLGFKYKKVRRSLARSLAIALLQKLCGALIFIFYGLNMLDCLRIRREFG 327
            ...:.:..|....:|.:|        ..:...:.|..||:|.|...|.:||..:.:.:.::..|.
Yeast   289 AVGNASWHELFSNKGAIL--------PRVIMGIVIQSLQQLTGCNYFFYYGTTIFNAVGMQDSFE 345

  Fly   328 LILCLGLILGFLACF---FLVDRLGRRPLLIFSSAGIVFVSIYLGLHFKVWMTMGLTVMSW---- 385
            ..:.||.: .|.:.|   ::||:.|||..|::.||.       :.:.|.::.|:|:|.: |
Yeast   346 TSIVLGAV-NFASTFVALYIVDKFGRRKCLLWGSAS-------MAICFVIFATVGVTRL-WPQGK 401

  Fly   386 ------------IALFCIAIFVGCYTAGVGSLTWVLNAELLVRPMRPL-----GCSIVCAFNWLT 433
                        |...|..||       ..::||...|.::|....||     ..:|....||:.
Yeast   402 DQPSSQSAGNVMIVFTCFFIF-------SFAITWAPIAYVIVAETYPLRVKNRAMAIAVGANWMW 459

  Fly   434 AF-------FVICWFG-SHGVKCQPYLFLLFAIIASLILLFSLIYIPETKKLSSAKIQQ 484
            .|       |:....| |:|     |:|:...|.:...:.|   ::.|||.|:..::.:
Yeast   460 GFLIGFFTPFITRSIGFSYG-----YVFMGCLIFSYFYVFF---FVCETKGLTLEEVNE 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glut3	NP_536732.1	Sugar_tr	60..484	CDD:278511	108/512 (21%)
Glut3	NP_536732.1	MFS	63..>226	CDD:119392	39/208 (19%)
HXT10	NP_116644.1	Sugar_tr	52..512	CDD:395036	108/514 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342382
Domainoid	1	1.000	165	1.000	Domainoid score	I819
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	165	1.000	Inparanoid score	I1037
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
TreeFam	0	0.000	Not matched by this tool.
	5	4.880