DRSC/TRiP Functional Genomics Resources

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Protein Alignment Glut3 and SLC2A4

DIOPT Version :9

Sequence 1:NP_536732.1 Gene:Glut3 / 42036 FlyBaseID:FBgn0015230 Length:507 Species:Drosophila melanogaster
Sequence 2:NP_001033.1 Gene:SLC2A4 / 6517 HGNCID:11009 Length:509 Species:Homo sapiens


Alignment Length:520 Identity:137/520 - (26%)
Similarity:222/520 - (42%) Gaps:100/520 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 GIQD--AEPVEPPQSSRKSGTWFAKRPSEMPERHVERAPVRQKINNVGLYKATLYSNIGSFFFGI 67
            |.|.  :|..|||| .|.:||                           |..|...:.:||..||.
Human     4 GFQQIGSEDGEPPQ-QRVTGT---------------------------LVLAVFSAVLGSLQFGY 40

  Fly    68 AVGWSGTAERSVMEQHSY--------------SFQPTELQ--WSGVCILLTLGAALWCLPMGLMV 116
            .:|.. .|.:.|:|| ||              |..|..|.  |:....:.::|..:....:|::.
Human    41 NIGVI-NAPQKVIEQ-SYNETWLGRQGPEGPSSIPPGTLTTLWALSVAIFSVGGMISSFLIGIIS 103

  Fly   117 RLLGCRRTILIQLLPNFLGWFLTVFAR---SVPMLYAGRFFLGMCGGAHCVVVPIYNAEISTTKK 178
            :.||.:|.:|:..:...||..|...|.   |..||..|||.:|...|....:||:|..||:.|..
Human   104 QWLGRKRAMLVNNVLAVLGGSLMGLANAAASYEMLILGRFLIGAYSGLTSGLVPMYVGEIAPTHL 168

  Fly   179 RGAMGVVFEGACICGVIYSFAMSLFLELRIINFVNLGLLALG----P--LQILM----PESPAY- 232
            |||:|.:.:.|.:.|::  .|..|.|| .::...:|..|.||    |  ||:::    ||||.| 
Human   169 RGALGTLNQLAIVIGIL--IAQVLGLE-SLLGTASLWPLLLGLTVLPALLQLVLLPFCPESPRYL 230

  Fly   233 YVDHGNIPRAEDSLRFLRG---------QKYDTRREIDFLTRDPTESEREVRQGPLLGFKYKKVR 288
            |:.......|..||:.|.|         :..|.:|::        |.||.:....|||.:..  |
Human   231 YIIQNLEGPARKSLKRLTGWADVSGVLAELKDEKRKL--------ERERPLSLLQLLGSRTH--R 285

  Fly   289 RSLARSLAIALLQKLCGALIFIFYGLNMLDCLRIRREFGLILCLGLI--LGFLACFFLVDRLGRR 351
            :.|..::.:.|.|:|.|.....:|..::.:...:.:.....:..|::  :..|....||:|.|||
Human   286 QPLIIAVVLQLSQQLSGINAVFYYSTSIFETAGVGQPAYATIGAGVVNTVFTLVSVLLVERAGRR 350

  Fly   352 PLLIFSSAGIVFVSIYLGLHFKVWMTMGLTV------MSWIALFCIAIFVGCYTAGVGSLTWVLN 410
            .|.:...||:...:|.        ||:.|.:      ||::::..|..||..:..|.|.:.|.:.
Human   351 TLHLLGLAGMCGCAIL--------MTVALLLLERVPAMSYVSIVAIFGFVAFFEIGPGPIPWFIV 407

  Fly   411 AELLVRPMRPLGCSIVCAFNWLTAFFVICWFGSHGVKCQPYLFLLFAIIASLILLFSLIYIPETK 475
            |||..:..||...::....||.:.|.:...|........||:|||||::.....:|:.:.:|||:
Human   408 AELFSQGPRPAAMAVAGFSNWTSNFIIGMGFQYVAEAMGPYVFLLFAVLLLGFFIFTFLRVPETR 472

  Fly   476  475
            Human   473  472

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Glut3NP_536732.1 Sugar_tr 60..484 CDD:278511 125/463 (27%)
MFS 63..>226 CDD:119392 54/187 (29%)
SLC2A4NP_001033.1 Interaction with SRFBP1. /evidence=ECO:0000269|PubMed:16647043 7..13 1/5 (20%)
Sugar_tr 27..483 CDD:306568 126/469 (27%)
Monosaccharide binding. /evidence=ECO:0000250|UniProtKB:P11166 298..304 3/5 (60%)
Dileucine internalization motif. /evidence=ECO:0000269|PubMed:8300557 489..490
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165144028
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X26
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.840

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