Protein Alignment Glut3 and SLC2A2

DIOPT Version :9

• Sequence 1: NP_536732.1
• Gene: Glut3 / 42036
• FlyBaseID: FBgn0015230
• Length: 507
• Species: Drosophila melanogaster
• Sequence 2: NP_000331.1
• Gene: SLC2A2 / 6514
• HGNCID: 11006
• Length: 524
• Species: Homo sapiens
• Alignment Length: 505
• Identity: 126/505 - (24%)
• Similarity: 217/505 - (42%)
• Gaps: 85/505 - (16%)

  Fly    60 IGSFFFGIAVGWSGTAERSVMEQH----------------------------SYSFQPTELQWS- 95
            :|||.||..:|.....::.::..:                            |||..|....|:
Human    19 LGSFQFGYDIGVINAPQQVIISHYRHVLGVPLDDRKAINNYVINSTDELPTISYSMNPKPTPWAE 83

  Fly    96 ----GVCILLTLGAALWCLPM--------------GLMVRLLGCRRTILIQLLPNFLGWFLTVFA 142
                ....|:|:   ||.|.:              |.:...||..:.:|:..:.:.:|..|..|:
Human    84 EETVAAAQLITM---LWSLSVSSFAVGGMTASFFGGWLGDTLGRIKAMLVANILSLVGALLMGFS 145

  Fly   143 RSVP---MLYAGRFFLGMCGGAHCVVVPIYNAEISTTKKRGAMGVVFEGACICGVIYSFAMSLFL 204
            :..|   ::.|||...|:..|....:||:|..||:.|..|||:|...:.|.:.|::.|  ..:.|
Human   146 KLGPSHILIIAGRSISGLYCGLISGLVPMYIGEIAPTALRGALGTFHQLAIVTGILIS--QIIGL 208

  Fly   205 ELRIINF----VNLGLLAL-GPLQILM----PESPAY-YVDHGNIPRAEDSLRFLRGQKYDTRRE 259
            |..:.|:    :.|||..: ..||.|:    ||||.| |:......:|:.||:.|||.. |..::
Human   209 EFILGNYDLWHILLGLSGVRAILQSLLLFFCPESPRYLYIKLDEEVKAKQSLKRLRGYD-DVTKD 272

  Fly   260 IDFLTRDPTESEREVRQGPLLGFKYKKVRRSLARSLAIALLQKLCGALIFIFYGLNMLDCLRIRR 324
            |:.:.::..|:..|.:...:..|.....|:.:..:|.:.:.|:..|.....:|..::.....|.:
Human   273 INEMRKEREEASSEQKVSIIQLFTNSSYRQPILVALMLHVAQQFSGINGIFYYSTSIFQTAGISK 337

  Fly   325 EFGLILCLGLI-LGFLA-CFFLVDRLGRRPLLIFSSAGIVFVSIYLGLHFKVWMTMGLTV----- 382
            .....:.:|.: :.|.| ..|||::.|||.|.:...:|:...:|:        |::||.:
Human   338 PVYATIGVGAVNMVFTAVSVFLVEKAGRRSLFLIGMSGMFVCAIF--------MSVGLVLLNKFS 394

  Fly   383 -MSWIALFCIAIFVGCYTAGVGSLTWVLNAELLVRPMRPLGCSIVCAFNWLTAFFVICWFGSHGV 446
             ||::::..|.:||..:..|.|.:.|.:.||...:..||...:|....||...|.|...|.....
Human   395 WMSYVSMIAIFLFVSFFEIGPGPIPWFMVAEFFSQGPRPAALAIAAFSNWTCNFIVALCFQYIAD 459

  Fly   447 KCQPYLFLLFAIIASLILLFSLIYIPETKKLSSAKIQ---QRLGGLINRP 493
            .|.||:|.|||.:.....||:...:||||..|..:|.   |:..|..:||
Human   460 FCGPYVFFLFAGVLLAFTLFTFFKVPETKGKSFEEIAAEFQKKSGSAHRP 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Glut3	NP_536732.1	Sugar_tr	60..484	CDD:278511	122/494 (25%)
		MFS	63..>226	CDD:119392	48/217 (22%)
SLC2A2	NP_000331.1	Sugar_tr	14..499	CDD:278511	122/493 (25%)
		MFS	98..485	CDD:119392	101/397 (25%)
		Monosaccharide binding. /evidence=ECO:0000250|UniProtKB:P11166	314..320		2/5 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144026
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850