DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Glut3 and Slc2a9

DIOPT Version :9

Sequence 1:	NP_536732.1	Gene:	Glut3 / 42036	FlyBaseID:	FBgn0015230	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_001178480.1	Gene:	Slc2a9 / 501925	RGDID:	1597012	Length:	545	Species:	Rattus norvegicus

Alignment Length:	529	Identity:	132/529 - (24%)
Similarity:	208/529 - (39%)	Gaps:	105/529 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 PVEPPQSSRKSGTWFAKRPSEMPERHVERAPVRQKINNVGLYKATLYSNIG-SFFFG-------- 66
            ||.||...|   .|               .|.|.|..:..|..|.|....| ||.:|
  Rat    22 PVGPPVGRR---GW---------------RPRRTKNWSCSLIVAALVGAFGSSFLYGYNLSVVNA 68

  Fly    67 ----IAVGWSGTAERSVMEQHSYSFQPTELQ--WSGVCILLTLGAALWCLPMGLMVRLLGCRRTI 125
                |...::.|..|    :|.....|..|.  ||....:..:|..:..|.:.::.:.||.:.|:
  Rat    69 PTPYIKAFYNETWYR----RHGQPIDPDTLTLLWSVTVSIFAIGGLVGTLMVKMIGKFLGRKYTL 129

  Fly   126 LIQ---LLPNFLGWFLTVFARSVPMLYAGRFFLGMCGGAHCVVVPIYNAEISTTKKRGAMGVVFE 187
            |:.   .:...|....::.|.:..||..|||.:|:.||.....:|:|..|||..:.||::|.| .
  Rat   130 LVNNGFAISAALLMACSLQAGTFEMLIVGRFIMGVDGGIALSALPMYLNEISPKEIRGSLGQV-T 193

  Fly   188 GACICGVIYSFAMSLFLEL-----------RIINFVNLGLLALGPLQILMPESPAY--YVDHGNI 239
            ...||..::|..:....||           .:|....|..||..|   .:||||.|  :..|...
  Rat   194 AIFICIGVFSGQLLGLPELLGKERTWPYLFGVIIVPALAQLASLP---FLPESPRYLLFEKHDEA 255

  Fly   240 PRAEDSLRFLRGQKYDTRREIDFLTRDPTESEREVRQGPLLGFKYKKVRRSLARSLAIALL---- 300
            ...:....||  .|.|..:|:     :...:|..|::...|...::.:|....|...|.::
  Rat   256 GATKAFQTFL--GKADVSQEL-----EEALAESRVQRNLRLVSVFELLRAPFVRWQVITVVITMA 313

  Fly   301 -QKLCGALIFIFYGLNMLDCLRIRREFG-----------LILCLGLILGFLACF--FLVDRLGRR 351
             .:|||.....||..::         ||           :.|..|.|....|.|  .:::|||||
  Rat   314 SYQLCGLNAIWFYTNSI---------FGKAGVPQDKIPYITLSTGGIETLAAIFSGLVIERLGRR 369

  Fly   352 PLLIFSSAGIVFVSIYLGLHFKVWMTMGLTVMS---WI---ALFCIAIFVGCYTAGVGSLTWVLN 410
            ||||   .|...::::.|:     :|:.||:..   ||   ::.||...:..:.:|.|.:.::|.
  Rat   370 PLLI---GGFGLMALFFGM-----LTVTLTLQDQAPWIPYLSIVCILAIIASFCSGPGGIPFILT 426

  Fly   411 AELLVRPMRPLGCSIVCAFNWLTAFFVICWFGSHGVKCQPYLFLLFAIIASLILLFSLIYIPETK 475
            .|...:..||....|....|||:.|.|...|.......:.|.||:||.|.....::....:||||
  Rat   427 GEFFQQSERPAAFIIAGTVNWLSNFVVGLLFPFIQKSLESYCFLVFATICIAGAIYFYFVLPETK 491

  Fly   476 KLSSAKIQQ 484
            ..:.|:|.|
  Rat   492 NRTHAEISQ 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glut3	NP_536732.1	Sugar_tr	60..484	CDD:278511	119/478 (25%)
Glut3	NP_536732.1	MFS	63..>226	CDD:119392	45/190 (24%)
Slc2a9	NP_001178480.1	Sugar_tr	47..502	CDD:278511	122/486 (25%)
Slc2a9	NP_001178480.1	MFS	49..486	CDD:119392	114/468 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337795
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.840