DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Glut3 and slc2a8

DIOPT Version :9

Sequence 1:	NP_536732.1	Gene:	Glut3 / 42036	FlyBaseID:	FBgn0015230	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_997963.1	Gene:	slc2a8 / 373140	ZFINID:	ZDB-GENE-030829-25	Length:	498	Species:	Danio rerio

Alignment Length:	491	Identity:	123/491 - (25%)
Similarity:	215/491 - (43%)	Gaps:	51/491 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 ERHVERAPVRQKINNVGLYKATLYSNIGSFFFGIAVGWSGTA--ERSVMEQHSYSFQPTELQWSG 96
            |...|:.....|:.|..|:.||..:.:|...||..:|:|..|  |...::.........|..|.|
Zfish    19 EDRSEQDAYLDKVKNGKLFIATFAAVLGPLSFGFVLGYSSPAIPELRRIQDLRLQLSVEEASWFG 83

  Fly    97 VCILLTLGAALWCLPMGLMVRLLGCRRTILIQLLPNFLGWFLTVFARSVPMLYAGRFFLGMCGGA 161
              .::|:||||..|..|.:|..:|.:.:::...:|...|:...:.|::..|.|.||...|:..|.
Zfish    84 --SVVTIGAALGGLLGGWIVERIGRKLSLMFCAIPFIFGFTTIIAAQNHWMFYVGRVLTGLASGV 146

  Fly   162 HCVVVPIYNAEISTTKKRGAMGVVFEGACICGVIYSFAMSLFLELRIINFVN-----LGLLALGP 221
            ..:|||:|.:|::..:.||.:|...:...:.|::.::...|||:.|.:...:     |.||::
Zfish   147 TSLVVPLYISEMAHERVRGTLGSCVQLMVVIGIMGAYVTGLFLDWRWLAVASSIPPTLMLLSM-- 209

  Fly   222 LQILMPESPAYYVDHGNIPRAEDSLRFLRGQKYDTRREIDFLTRDPTESEREVRQGPLLGFKYKK 286
              ..|||:|.:.:..|....|||:||||||.......|...:.......|:....|.|   |...
Zfish   210 --CFMPETPRFLLCQGKRREAEDALRFLRGPDAPAEWECARIEDAYKNEEQSFSLGDL---KDPG 269

  Fly   287 VRRSLARSLAIALLQKLCGALIFIFYGLNMLDCLRIR-REFGLILCLGLILGFLACFFLV-DRLG 349
            |.:.|...:.:.|||:..|....:||...:.:....: .:...::.....:.|.|...|: |:.|
Zfish   270 VYKPLGIGVMMMLLQQFTGINAIMFYAETIFEQAHFKSSDVATVIVAATQVVFTAIAALIMDKAG 334

  Fly   350 RRPLLIFSSAGIVFVSIYLGLHFKVW--------MTMGLT------------VMSWIALFCIAIF 394
            |:.|||.|...:.......|::||:.        ||..||            .::|:|:..:..|
Zfish   335 RKVLLILSGVVMCVSEAVFGVYFKLTVMKPNNSSMTSVLTDTHGLLEDQPSADLAWLAVGSMGFF 399

  Fly   395 VGCYTAGVGSLTWVLNAELLVRPMRPLGCSIVCAFNWLTAFFVICWF-------GSHGVKCQPYL 452
            :..:..|.|...|::.:|:....:|.||.::....||..||.|...|       .|.|.
Zfish   400 IAGFAIGWGPTPWLVMSEIFPTRVRGLGSALCVLTNWTCAFIVTKTFQNLMDALSSAGT------ 458

  Fly   453 FLLFAIIASLILLFSLIYIPETKKLSSAKIQQRLGG 488
            |.:|:.:.:..::|:..::||||..:..:||....|
Zfish   459 FWMFSALCASNVVFTAFFVPETKGKTLEEIQAGFKG 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glut3	NP_536732.1	Sugar_tr	60..484	CDD:278511	114/459 (25%)
Glut3	NP_536732.1	MFS	63..>226	CDD:119392	43/169 (25%)
slc2a8	NP_997963.1	Sugar_tr	39..492	CDD:278511	117/467 (25%)
slc2a8	NP_997963.1	MFS	40..477	CDD:119392	110/451 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576916
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52445
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	1	1.000	-	-		FOG0000275
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48021
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.960