DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Glut3 and CG4607

DIOPT Version :9

Sequence 1:	NP_536732.1	Gene:	Glut3 / 42036	FlyBaseID:	FBgn0015230	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_572380.1	Gene:	CG4607 / 31653	FlyBaseID:	FBgn0029932	Length:	525	Species:	Drosophila melanogaster

Alignment Length:	537	Identity:	118/537 - (21%)
Similarity:	213/537 - (39%)	Gaps:	97/537 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GIQDAEPVEPPQSSRKSGTWFAKRPSEM-----PERHVERAP--------VRQKINNVGLYKATL 56
            |.|:.:.|.||          |.:|:.:     .:.|.:..|        :||::       ...
  Fly     3 GQQEEQLVPPP----------AYKPTVVAKDTTKDSHAKEKPLGEGRLAVLRQEL-------MVF 50

  Fly    57 YSNIGSFFFGIAVGWSG-TAERSVMEQHSYSFQPTELQWSGVCILLTLGAALWCLPMGLMVRLLG 120
            ..|.|....|:.|.... |..:...|...:.....|..|  ...:..:...|..|.:...:..:|
  Fly    51 LGNSGVLGSGMVVSMPAVTLNQLHDETQPFWLNKDESSW--FASIQNMACPLGGLLVSYFLDRIG 113

  Fly   121 CRRTILIQLLPNFLGWFL--TVFARS-VPMLY----AGRFFLGMCGGAHCVVVPIYNAEISTTKK 178
            .:.|||:..|...:||.|  |.|..| ..|:|    .||.|.|:..|.....|.:|:||||..|.
  Fly   114 RKHTILLTNLIGLIGWILLVTSFMHSDRDMIYYQMLLGRCFGGIMIGMFVSPVGVYSAEISLPKI 178

  Fly   179 RGAMGVVFEGACICGVIYSFAMSLFLELRIINFVNLGL---LALGPLQILMPESPAYYVDHGNIP 240
            ||.:.:........|::..:.:..|:...|.....:..   ||...|...|||||::.:..|...
  Fly   179 RGRLILGTSLGLASGILLMYCLGYFIRHNIQLIFGISCCYQLAATLLVFPMPESPSWLLTRGKEE 243

  Fly   241 RAEDSLRFLRGQKYDTRREIDFL---------TRDPTESEREVRQGPLLG--FKYKKVRRSLARS 294
            ||..|||:.||.   .::|:|::         .::..::......|..|.  ....:|.:.:...
  Fly   244 RARKSLRYFRGL---PKKEVDYVPEFEAELAHMKELADASNTTAAGESLSQMIHRPEVYKPVLMM 305

  Fly   295 LAIALLQKLCGALIFIFYGLNMLDCLRIRREFGLIL---CLGLILG--------FLACFFLVDRL 348
            ......|:.||.::.|.|      .::|.::.|:.:   .:.::||        |::..|  ::.
  Fly   306 TTFFGFQQACGVVVIIVY------AVQIAQQAGVTIDPVLVAVMLGVARIITTLFMSGIF--EKW 362

  Fly   349 GRRPLLIFSSAGIVFVSIYL-GLHFKVWMTMGLTVMSWIALFCIAIFVGCYTAGVGSLTWVLNAE 412
            ||:|..|||:.|:....:.| |.:   |....|..:.|:.:.||...:...|.|:.:|.:.:.:|
  Fly   363 GRKPSGIFSATGMGACMLLLAGGN---WFPDTLGTLHWLPVACIVAHIVFSTMGMLTLPFFMISE 424

  Fly   413 LLVRPMRPLGCSIVCAFNWLTAFFVICWFGSHGVKCQP---------YLFLLFAIIASLILLFSL 468
            :..:..|.....|...|..:.||.::        |..|         .||..:|.|:.|...|..
  Fly   425 VFPQRARGSASGIAIFFGMILAFIML--------KIYPNMEAALGTANLFAFYAGISFLAAAFIG 481

  Fly   469 IYIPETKKLSSAKIQQR 485
            :::|||:..:..::::|
  Fly   482 VFVPETRGRTLEELEER 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glut3	NP_536732.1	Sugar_tr	60..484	CDD:278511	105/466 (23%)
Glut3	NP_536732.1	MFS	63..>226	CDD:119392	41/173 (24%)
CG4607	NP_572380.1	MFS	55..484	CDD:119392	102/452 (23%)
CG4607	NP_572380.1	SP	67..495	CDD:273317	102/451 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45444400
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4448
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48021
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.800