DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Glut3 and Slc2a12

DIOPT Version :9

Sequence 1:	NP_536732.1	Gene:	Glut3 / 42036	FlyBaseID:	FBgn0015230	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_001100921.1	Gene:	Slc2a12 / 308028	RGDID:	1310175	Length:	621	Species:	Rattus norvegicus

Alignment Length:	550	Identity:	110/550 - (20%)
Similarity:	206/550 - (37%)	Gaps:	135/550 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 GLYKATLYSNIGSFFFGIAVGWS-GTAERSVMEQHSYSFQPTELQWSGVCILLTLGAALWCLPMG 113
            |::  |..:::.:...|:.||:. |....::::..:........|...|..|| :||.|..|..|
  Rat    41 GMF--TFLTSVTAAISGLLVGYELGLISGALLQIRTLLALTCHEQEMVVSSLL-IGAFLASLTGG 102

  Fly   114 LMVRLLGCRRTILIQLLPNFLGWFLTVFARSVPMLYAGRFFLGMCGGAHCVVVPIYNAEISTTKK 178
            :::...|.|.||::......||..:.:.:.|..:|..||..:|:......:...:|.|||:...:
  Rat   103 VLIDRYGRRLTIILSSCLLGLGSLVLILSLSYTLLITGRVAIGVSISLSSIATCVYIAEIAPQHR 167

  Fly   179 RGAMGVVFEGACICGVIYSFAMSLFLELRIIN--FVNLG---------LLALGPLQIL----MPE 228
            ||.:..:.|...:.|:::::         |.|  |.|:.         ::.||.||.:    :|.
  Rat   168 RGLLVSLNELMIVTGILFAY---------ISNYAFANISNGWKYMFGLVIPLGVLQAIAMYFLPP 223

  Fly   229 SPAYYVDHGNIPRAEDSLRFLRGQKYDTRREIDFLTRDPTESEREVRQGPLLGFKYK-KVRRSLA 292
            ||.:.|..|....|...||.||... ||..|:. |.:...:.|.:.....|  |:.| .:|..:.
  Rat   224 SPRFLVMKGQEEAAGKVLRKLRVIS-DTAEELT-LIKSSLKDEYQYSFWDL--FRSKDNMRTRIL 284

  Fly   293 RSLAIALLQKLCGALIFIFYGLNMLDCLRIR-REFGLILCLGL----ILGFLACFFLVDRLGRRP 352
            ..|.:....:..|....:||...:|..:..: .|...:...|:    ::..:....|||.:|.:.
  Rat   285 IGLTLVFFVQTTGQPNILFYASTVLKSVGFQSNEAASLASTGVGVVKVVSTIPATLLVDHVGSKT 349

  Fly   353 LLIFSSA---------GIVFVSI----------------------------------YLGLHFK- 373
            .|...|:         |||.::|                                  .||.|.|
  Rat   350 FLCIGSSVMAASLLTMGIVNLNINMNFTNICRSHSPLNQSLEELVFYATGNLSVSNSSLGEHLKR 414

  Fly   374 -------VWMTMG---------------------------------LTVMSWIALFCIAIFVGCY 398
                   :::.:|                                 ..|..|::|..:.::|..:
  Rat   415 VTPYSKGLFIPLGNGMEPKGEMAFTSLPNAGLSRTDRQGVTDPAVVPAVYKWLSLASLLVYVAAF 479

  Fly   399 TAGVGSLTWVLNAELLVRPMRPLGCSIVCAFNW-------LTAFFVICWFGSHGVKCQPYLFLLF 456
            :.|:|.:.|::.:|:....:|....::..:.||       ||...|....|...| |     .::
  Rat   480 SIGLGPMPWLVLSEIFPGGIRGRAMALTSSMNWGINLLISLTFLTVTDLIGLSWV-C-----FIY 538

  Fly   457 AIIASLILLFSLIYIPETKKLSSAKIQQRL 486
            .:::...|.|.:::|||||..|..:|...|
  Rat   539 TVMSLTSLAFVVLFIPETKGCSLEQISMEL 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glut3	NP_536732.1	Sugar_tr	60..484	CDD:278511	107/536 (20%)
Glut3	NP_536732.1	MFS	63..>226	CDD:119392	40/178 (22%)
Slc2a12	NP_001100921.1	MFS_GLUT12_Class3	46..564	CDD:340993	106/537 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337797
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840