DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Glut3 and Slc2a3

DIOPT Version :9

Sequence 1:	NP_536732.1	Gene:	Glut3 / 42036	FlyBaseID:	FBgn0015230	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	XP_006237357.1	Gene:	Slc2a3 / 25551	RGDID:	3706	Length:	495	Species:	Rattus norvegicus

Alignment Length:	458	Identity:	118/458 - (25%)
Similarity:	197/458 - (43%)	Gaps:	52/458 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 ATLYSNIGSFFFGIAVGWSGTAERSVMEQHSYSFQ------PTE----LQWSGVCILLTLGAALW 108
            |...:.||||.||...|.....|..:.:..:|:.:      |:|    ..||....:.::|..:.
  Rat    15 AVTVATIGSFQFGYNTGVINAPETIIKDFLNYTLEERLEDLPSEGLLTTLWSLCVAIFSVGGMIG 79

  Fly   109 CLPMGLMVRLLGCRRTILIQLLPNFLGWFLTVFAR---SVPMLYAGR----FFLGMCGGAHCVVV 166
            ...:||.|...|.|.::|:..|...||..|..||:   ||.||..||    .|.|:|.|    .|
  Rat    80 SFSVGLFVNRFGRRNSMLLVNLIAILGGCLMGFAKIAESVEMLILGRLIIGIFCGLCTG----FV 140

  Fly   167 PIYNAEISTTKKRGAMGVVFEGACICGVIYSFAMSLFLELRIINFVNL--GLLALGPLQILM--- 226
            |:|..|:|.|..|||.|.:.:...:.|::.:....|..   |:....|  |||.|..:..::
  Rat   141 PMYIGEVSPTALRGAFGTLNQLGIVVGILVAQVFGLDF---ILGSEELWPGLLGLTIIPAILQSA 202

  Fly   227 -----PESPAY-YVDHGNIPRAEDSLRFLRGQKYDTRREIDFLTRDPTESEREVRQGPLLGFKYK 285
                 ||||.: .::.....:|.:.|:.|.|.. |..:||..:..:.....:|.:...|..||..
  Rat   203 ALPFCPESPRFLLINRKEEDQATEILQRLWGTP-DVIQEIQEMKDESIRMSQEKQVTVLELFKSP 266

  Fly   286 KVRRSLARSLAIALLQKLCGALIFIFYGLNMLDCLRIRREFGLILCLGLI--LGFLACFFLVDRL 348
            ...:.|..|:.:.|.|:..|.....:|...:.....::......:..|::  :..:...|||:|.
  Rat   267 SYFQPLLISVVLQLSQQFSGINAVFYYSTGIFQDAGVQEPIYATIGAGVVNTIFTVVSLFLVERA 331

  Fly   349 GRRPLLIFSSAGIVFVSIYLGLHFKVWMTMGLTV------MSWIALFCIAIFVGCYTAGVGSLTW 407
            |||.|.:....|:...|::        ||:.|.:      ||::.:..|.::|..:..|.|.:.|
  Rat   332 GRRTLHMIGLGGMAVCSVF--------MTISLLLKDEYEAMSFVCIVAILVYVAFFEIGPGPIPW 388

  Fly   408 VLNAELLVRPMRPLGCSIVCAFNWLTAFFVICWFGSHGVKCQPYLFLLFAIIASLILLFSLIYIP 472
            .:.|||..:..||...::....||.:.|.|..:|.|.......|:|::||......|:|:...:|
  Rat   389 FIVAELFSQGPRPAAMAVAGCSNWTSNFLVGMFFPSAAAYLGAYVFIIFAAFLVFFLIFTFFKVP 453

  Fly   473 ETK 475
            |||
  Rat   454 ETK 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glut3	NP_536732.1	Sugar_tr	60..484	CDD:278511	117/452 (26%)
Glut3	NP_536732.1	MFS	63..>226	CDD:119392	51/181 (28%)
Slc2a3	XP_006237357.1	Sugar_tr	15..467	CDD:278511	118/458 (26%)
Slc2a3	XP_006237357.1	MFS	16..450	CDD:119392	113/449 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337739
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.840