DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Glut3 and Slc2a2

DIOPT Version :9

Sequence 1:	NP_536732.1	Gene:	Glut3 / 42036	FlyBaseID:	FBgn0015230	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_037011.2	Gene:	Slc2a2 / 25351	RGDID:	3705	Length:	522	Species:	Rattus norvegicus

Alignment Length:	530	Identity:	127/530 - (23%)
Similarity:	217/530 - (40%)	Gaps:	112/530 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 IGSFFFGIAVGWSGTAERSVMEQH---------------SYSFQPT----------------ELQ 93
            :|||.||..:|.....:..::..:               :|....|                |.:
  Rat    19 LGSFQFGYDIGVINAPQEVIISHYRHVLGVPLDDRRATINYDINGTDTPLIVTPAHTTPDAWEEE 83

  Fly    94 WSGVCILLTLGAALWCLPM------GLMVRLLGCRRTILIQLLPNFLGWFLTVFARSVPMLYA-- 150
            ..|...::|:   ||.|.:      |::....|              ||......|...||.|
  Rat    84 TEGSAHIVTM---LWSLSVSSFAVGGMVASFFG--------------GWLGDKLGRIKAMLAANS 131

  Fly   151 ----GRFFLGMC---GGAHCVV-----------------VPIYNAEISTTKKRGAMGVVFEGACI 191
                |...:| |   |.||.::                 ||:|..||:.|..|||:|.:.:.|.:
  Rat   132 LSLTGALLMG-CSKFGPAHALIIAGRSVSGLYCGLISGLVPMYIGEIAPTTLRGALGTLHQLALV 195

  Fly   192 CGVIYS--FAMSLFLELRIINFVNLGLLAL-GPLQILM----PESPAY-YVDHGNIPRAEDSLRF 248
            .|::.|  ..:|..|..:....:.|||.|: ..||.|:    ||||.| |:......||:.||:.
  Rat   196 TGILISQIAGLSFILGNQDYWHILLGLSAVPALLQCLLLLFCPESPRYLYLKLEEEVRAKKSLKR 260

  Fly   249 LRGQKYDTRREIDFLTRDPTESEREVRQGPLLGFKYKKVRRSLARSLAIALLQKLCGALIFIFYG 313
            |||.: |..::|:.:.::..|:..|.:...:..|.....|:.:..:|.:.|.|:..|.....:|.
  Rat   261 LRGTE-DVTKDINEMRKEKEEASTEQKVSVIQLFTDPNYRQPIVVALMLHLAQQFSGINGIFYYS 324

  Fly   314 LNMLDCLRIRREFGLILCLGLI-LGFLA-CFFLVDRLGRRPLLIFSSAGIVFVSIYLGLHFKVWM 376
            .::.....|.:.....:.:|.| :.|.| ...||::.|||.|.:....|:.|.:::        |
  Rat   325 TSIFQTAGISQPVYATIGVGAINMIFTAVSVLLVEKAGRRTLFLAGMIGMFFCAVF--------M 381

  Fly   377 TMGL------TVMSWIALFCIAIFVGCYTAGVGSLTWVLNAELLVRPMRPLGCSIVCAFNWLTAF 435
            ::||      |.||::::..|.:||..:..|.|.:.|.:.||...:..||...::....||:..|
  Rat   382 SLGLVLLDKFTWMSYVSMTAIFLFVSFFEIGPGPIPWFMVAEFFSQGPRPTALALAAFSNWVCNF 446

  Fly   436 FVICWFGSHGVKCQPYLFLLFAIIASLILLFSLIYIPETKKLS----SAKIQQRLGGLINRPAVI 496
            .:...|........||:|.|||.:..:..||:...:||||..|    :|:.:::.|....|.|.:
  Rat   447 IIALCFQYIADFLGPYVFFLFAGVVLIFTLFTFFKVPETKGKSFDEIAAEFRKKSGSAPPRKAAV 511

  Fly   497 --TFTSSSDS 504
              .|..||::
  Rat   512 QMEFLGSSET 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glut3	NP_536732.1	Sugar_tr	60..484	CDD:278511	121/506 (24%)
Glut3	NP_536732.1	MFS	63..>226	CDD:119392	47/228 (21%)
Slc2a2	NP_037011.2	MFS_GLUT_Class1	12..488	CDD:340989	119/495 (24%)
Slc2a2	NP_037011.2	Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	312..318		2/5 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337789
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.850